吉林农业大学学报2023,45(1):1-8http://xuebao.jlau.edu.cnE⁃mail:jlndxb@vip.sina.comJournalofJilinAgriculturalUniversity寄生蜂细胞色素P450s研究进展*任炳忠1,2**,纪若云1,2,陈琪1,2**1.东北师范大学生命科学学院,长春130024;2.吉林省动物资源保护与利用省级重点实验室,长春130024摘要:细胞色素P450s广泛存在于植物、动物和微生物中,对昆虫内源性物质的合成、代谢和对外源物质的解毒均发挥着重要作用,也与昆虫抗药性的产生密切相关。近年来,化学杀虫剂的过度使用严重威胁着天敌昆虫寄生蜂的生存,降低其作为生物防治剂的防治效果。昆虫耐药性的产生很大程度上依赖于细胞色素P450s对外源有毒物质的代谢作用,因此,对寄生蜂P450s基因进行鉴定和进化分析,了解其介导的抗药性机制,对指导新型农药的开发、通过基因编辑的方法改造寄生蜂P450s基因以增强其对化学药剂的耐受性等,均具有重要研究意义和应用价值。关键词:寄生蜂;细胞色素P450s;杀虫剂;抗药性中图分类号:S476+.3文献标志码:A文章编号:1000-5684(2023)01-0001-08DOI:10.13327/j.jjlau.2022.1692引用格式:任炳忠,纪若云,陈琪.寄生蜂细胞色素P450s研究进展[J].吉林农业大学学报,2023,45(1):1-8.ResearchProgressoftheCytochromeP450sinParasitoidWasps*RENBingzhong1,2**,JIRuoyun1,2,CHENQi1,2**1.CollegeofLifeSciences,NortheastNormalUniversity,Changchun130024,China;2.JilinPro⁃vincialKeyLaboratoryofAnimalResourceConservationandUtilization,Changchun130024,ChinaAbstract:CytochromeP450s,widelyfoundinplants,animalsandmicroorganisms,playanimpor⁃tantroleinsynthesis,metabolismofhormonesanddetoxificationofexogenoussubstanceininsects.Theyarealsocloselyrelatedtothedevelopmentofinsecticideresistance.Inrecentyears,theindis⁃criminateuseofinsecticideshasseriouslythreatenedtheexistenceofparasitoids,andweakenedtheeffectofparasitoidsasbiologicalcontrolagents.ThegenerationofdrugresistanceofinsectsdependsonthemetabolismofcytochromeP450stoexogenoustoxicsubstancestoagreatextent.Therefore,theidentificationandevolutionaryanalysisoftheP450sgenesofparasitoidsarecarriedouttoclarifythemechanismofdrugresistancemediatedbythesegenes,hopingtoprovidetheoreticalandtechni⁃calsuppo...