DOI:10.3969/j.issn.1672-7770.2023.02.021·综述·内囊前肢在外科治疗精神疾病中的运用进展何伟斌,李宸辉,邵灵敏,王高华,易伟【摘要】约30%~40%的精神疾病患者对药物、心理疗法和其他治疗方式多模式综合治疗后反应不佳或无效,从而进展为难治性精神疾病。神经调控技术运用于治疗难治性精神疾病已有60多年历史。近年来,越来越多的神经影像学研究发现精神疾病发病与神经环路功能障碍有关。内囊前肢(ALIC)是这些神经环路中的关键节点,调控ALIC在治疗强迫症(OCD)、重度抑郁症等精神疾病显得越来越重要,本文就ALIC的解剖学、神经影像学及在难治性精神疾病的运用进展做一综述。【关键词】内囊前肢;脑网络;神经影像学;精神疾病;强迫症【中图分类号】R651.1+1【文献标志码】A【文章编号】1672-7770(2023)02-0224-07ApplicationprogressofanteriorlimbofinternalcapsuleintreatmentofpsychiatricdiseasesHEWei-bin,LIChen-hui,SHAOLing-min,etal.DepartmentofNeurosurgery,RenminHospitalofWuhanUniversity,Wuhan430071,ChinaCorrespondingauthor:YIWeiAbstract:About30%-40%psychiatricpatientsrespondpoorlytomultimodalcomprehensivetreatmentincludingdrugs,psychotherapyandothertreatmentmethods,andwillfurtherprogresstorefractorypsychiatricpatient.Neuromodulationtechnologyhasbeenusedinthetreatmentofrefractorypsychiatricdiseasesformorethan60years.Moreandmoreneuroimagingstudieshavefoundthatthepathophysiologyofmentaldisordersisrelatedtothedysfunctionofneuralcircuits.Theanteriorlimboftheinternalcapsule(ALIC)isakeypointintheneuralcircuit.RegulationALICisbecomingmoreandmoreimportantinthetreatmentofrefractoryobsessive-compulsivedisorder(OCD),severedepression,andothermentaldiseases.Thispaperreviewstheanatomy,neuroimagingandapplicationprogressofALICinrefractorymentaldiseases.Keywords:anteriorlimboftheinternalcapsule;brainnetwork;neuroimaging;psychiatricdisorder;obsessivecompulsivedisorder基金项目:武汉大学医学腾飞计划基金项目(TFLC2018001)作者单位:430071武汉,武汉大学人民医院神经外科(何伟斌,李宸辉,邵灵敏,易伟),精神科(王高华)通信作者:易伟大多数精神疾病患者可以通过药物治疗、心理治疗、物理治疗(如电休克治疗、经颅磁治疗)或几种方案的联...