第37卷第2期2023年4月长治医学院学报JOURNALOFCHANGZHIMEDICAICOLLEGEVol.37No.2Apr.2023作者单位:运城市中心医院生殖医学科(山西运城044000)作者简介:景霞,女,硕士,主治医师,研究方向:生殖内分泌;通信作者:朱爱珍,女,本科,主任医师,研究方向:生殖内分泌;E-mail:zhua-izhen8768@163.com。激素替代周期内膜转化日血清雌二醇水平对冻融胚胎移植临床结局的影响景霞孙亚婷李晓霞朱爱珍摘要目的:探讨激素替代周期(HRT)内膜转化日血清雌二醇(E2)水平对冻融胚胎移植(FET)临床结局的影响。方法:回顾性分析首次行激素替代周期冻融胚胎移植(HRT-FET)的374个周期的临床资料,根据内膜转化日血清E2水平中位数将374个周期分为低水平组(n=194,E2<400pg·mL-1)和高水平组(n=180,E2≥400pg·mL-1)。比较2组临床结局指标,包括生化妊娠率、临床妊娠率、流产率、活产率。结果:高水平组和低水平组的生化妊娠率、临床妊娠率和流产率差异无统计学意义(P>0.05);低水平组的活产率(61.86%)高于高水平组(51.67%),差异有统计学意义(P<0.05)。结论:HRT内膜转化日血清高E2水平会降低FET的活产率。关键词激素替代周期;雌二醇;冻融胚胎移植;临床结局中图分类号R321.33文献标志码A文章编号1006-0588(2023)02-0106-04EffectsofSerumEstradiolLevelsonEndometrialTransformationDayinHormoneReplacementCycleonClinicalOutcomeofFrozen-ThawedEmbryoTransferJINGXia,SUNYating,LIXiaoxia,ZHUAizhenAssistedReproductionCenterofYunchengCentralHospitalAbstractObjective:Toinvestigatetheeffectofserumestradiol(E2)levelonendometrialtransformationdayinthehormonereplacementcycleontheclinicaloutcomeoffrozen-thawedembryotransfer(FET).Methods:Thisstudywasaretrospectivestudy.374cyclesofhormonereplacementcyclefreeze-thawembryotransfer(HRT-FET)wereselectedinourcenter.The374cyclesweredividedintotwogroupsaccordingtothemedianserumE2level:low-levelgroup(n=194,E2<400pg·mL-1);high-levelgroup(n=180,E2≥400pg·mL-1).Theclinicaloutcomeindexesofthetwogroupswerecompared,includingbiochemicalpregnancyrate,clinicalpregnancyrate,abortionrate,andlivebirthrate.Results:Therewerenosignificantdifferencesinbiochemicalpregnancyrate,clinicalpregnancyrate,andabortionratebetweenthehigh-levelgroupandthelow-levelgroup(P>0.05).Thelivebirthrateinthelo...
