·综述·肺泡气流空气动力学数值模拟计算研究进展欧新颖1，罗凤鸣2，万华靖2，王昭力1，阮畅1，陈宇11.四川大学力学科学与工程系，四川省生物力学工程实验室（成都610065）2.四川大学华西医院呼吸与危重症医学科，肺免疫炎症研究室（成都610041）【摘要】肺部疾病因其种类繁多、成因复杂、发病率高、治疗困难等，已成为威胁人类生命健康的一大杀手，部分疾病会对肺泡形态学和组织学产生较为明显的影响。基于计算流体力学的肺泡数值模拟，即对肺泡力学响应及肺泡内流场信息、多相流、物质传递等方面进行数值模拟，对肺部疾病诊断、临床治疗和体外实验有重大意义。该文从几何模型和力学模型的简化及病理差异入手，分析并总结了其在肺泡气流动力学计算方法的条件设置与应用场景，以为肺泡区开展进一步的模拟与应用提供参考。【关键词】肺泡；肺部疾病；数值模拟；计算流体力学；几何模型ResearchprogressincomputationalfluiddynamicssimulationofalveolarairflowsOUXinying1,LUOFengming2,WANHuajing2,WANGZhaoli1,RUANChang1,CHENYu11.DepartmentofAppliedMechanics,SichuanProvinceBiomechanicalEngineeringLaboratory,SichuanUniversity,Chengdu,Sichuan610065,P.R.China2.DepartmentofPulmonaryandCriticalCareMedicineandLaboratoryofPulmonaryImmunologyandInflammation,WestChinaHospital,SichuanUniversity,Chengdu,Sichuan610041,P.R.ChinaCorrespondingauthor:CHENYu,Email:yu_chen@scu.edu.cn【Abstract】Duetotheirdiversetypes,complexcauses,highincidence,anddifficulttreatment,lungdiseaseshavebecomemajorkillersthreateninghumanlifeandhealth,andsomelungdiseaseshaveasignificantimpactonalveolarmorphologyandhistology.Numericalsimulationofalveolarmechanicalresponse,alveolarflowfieldinformation,multiphaseflow,andmaterialtransportbasedoncomputationalfluiddynamicsisofgreatsignificanceforlungdiseasediagnosis,clinicaltreatment,andinvitroexperiments.Startingfromthesimplificationandpathologicaldifferencesofgeometricandmechanicalmodels,thispaperanalyzesandsummarizestheconditionsandapplicationscenariosoftheairflowdynamicscalculationmethodinpulmonaryalveoli,toprovideareferenceforfurthersimulationandapplicationofthealveolarregion.【Keywords】Pulmonaryalveoli;lungdiseases;numericalsi...
