临床医学研究与实践2023年4月第8卷第12期临床医学StudyandvalueofplacentalpathologyingestationaldiabetesmellitusSHENJianhua(PathologyDepartment,MaternalandChildHealthHospitalofYunfu,Yunfu527300,China)ABSTRACT:ObjectiveToanalyzetheplacentalpathologicalchangesofpregnantwomenwithgestationaldiabetesmellitus(GDM)anditseffectonpregnancyoutcome.MethodsSixtypregnantwomenwithGDMwhounderwentpre-pregnancyexaminationanddeliveredinMaternalandChildHealthHospitalofYunfufromJune2021toFebruary2023wereselectedasobservationgroup,and60pregnantwomenwithnormalGDMscreeningtestduringthesameperiodwereselectedascontrolgroup.Theuterinearteryhemodynamicparameters,netweightofplacenta,neonatalbirthweight,placentalcoefficient,averagethicknessofsyncytiotrophoblastbasementmembrane,averagethicknessofcapillarybasementmembrane,occurrenceofmorphologicalchangesofplacentalvilliandpregnancyoutcomeswerecomparedbetweenthetwogroups.ResultsThepulsatilityindex(PI),resistanceindex(RI)andtheratioofmaximumsystolicbloodflowvelocitytoenddiastolicbloodflowvelocity(S/D)intheobservationgroupwerehigherthanthoseinthecontrolgroup,andthedifferenceswerestatisticallysignificant(P<0.05).Thenetweightofplacenta,neonatalbirthweight,placentalcoefficient,averagethicknessofsyncytiotrophoblastbasementmembraneandaveragethicknessofcapillarybasementmembraneintheobservationgroupweregreaterthanthoseinthecontrolgroup,andthedifferenceswerestatisticallysignificant(P<0.05).Theincidencesofsmallarterywallthickeningandiumenstenosis,poorvillusmaturationandinterstitialcapillarydilatationfillingintheobservationgroupwerehigherthanthoseinthecontrolgroup,andthedifferenceswerestatisticallysignificant(P<0.05).Theincidencesofneonatalasphyxia,neonatalhypoglycemiaandneonatalhyperbilirubinemiaintheobservationgroupwerehigherthanthoseinthecontrolgroup,andthedifferenceswerestatisticallysignificant(P<0.05).ConclusionGDMcanaffecttheuterine-placentalbloodcirculation,leadingtoplacentalpathologicalchanges,therebyaffectingfetalgrowthanddevelopment.Therefore,clinica...
