第14卷第4期2023年7月Vol.14No.4Jul.2023器官移植OrganTransplantation·综述·扩大供心来源的最新研究进展袁顺王志维【摘要】随着心脏移植手术技术逐步成熟、免疫抑制药广泛使用以及器官分配系统完善,供心来源不足已成为制约临床心脏移植发展的瓶颈,如何扩大供心来源是亟待解决的科学难题。近年,随着科学技术的发展以及新型技术的应用,移植界就如何扩大供心来源取得了许多突破性的进展,许多研究成果已逐步实现临床转化,推动了临床心脏移植的发展。因此,本文就扩大供心来源的最新技术及策略进行综述,重点探讨器官保存技术、边缘供心使用、异种移植、人工心脏以及生物人工心脏在缓解供心短缺中的作用,概述扩大供心来源当前所面临的挑战和未来方向,以期为临床心脏移植的进一步发展提供参考。【关键词】心脏移植;心力衰竭;供者短缺;器官保存;边缘供心;异种移植;人工心脏;生物人工心脏【中图分类号】R617,R541【文献标志码】A【文章编号】1674-7445(2023)04-0016-07【Abstract】Withgradualmaturityofsurgicaltechniqueofhearttransplantation,extensiveuseofimmunosuppressantsandtheimprovementoforgandistributionsystem,theshortageofdonorhearthasbecomeabottleneckissuerestrictingthedevelopmentofhearttransplantationinclinicalpractice.Howtoexpandthedonorpoolforhearttransplantationremainstobeurgentlysolved.Inrecentyears,withthedevelopmentofscienceandtechnologyandtheapplicationofnewtechnology,groundbreakingprogresseshavebeenmadeonhowtoexpandthedonorpoolforhearttransplantationwithinthetransplantationcommunity.Multipleresearchresultshavebeengraduallytranslatedintoclinicalpractice,drivingthedevelopmentofhearttransplantationinclinicalsettings.Inthisarticle,thelatesttechnologiesandstrategiestoexpandthedonorpoolforhearttransplantationwerereviewed,therolesoforganpreservationtechnology,useofmarginaldonorheart,xenotransplantation,artificialheartandbioartificialheartinalleviatingtheshortageofdonorheartwereinvestigated,andexistingchallengesandfuturedirectionstoexpandthedonorpoolforhearttransplantationweresummarized,aimingtoprovidereferenceforsubsequentdevelopmentofhearttransplantationinclinicalpractice.【Keywords】Hearttransplantation;Heartfailu...