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（Biomedical Transformation），2023年6月，第4卷，第2期dependent mannerJ.Mol Cell Biochem,2011,355(1-2):211-216.32 MORSCZECK C,RECK A,REICHERT T E.Wnt3a andthe induction of the osteogenic differentiation in adiposetissue derived mesenchymal stem cellsJ.Tissue Cell,2017,49(4):489-494.33 何伟,陈荣春,曾芳俊,等.骨髓间充质干细胞来源的外泌体对骨再生机制研究J.中国骨质疏松杂志,2019,25(4):477-483.34 叶涛,李永忠,付爱华,等.外泌体与Wnt3a联合诱导间充质干细胞归巢及定向分化J.华中科技大学学报(医学版),2019,48(6):637-643.35 XIE Y,CHEN Y,ZHANG L,et al.The roles of bone-derivedexosomesandexosomalmicroRNAsinregulating bone remodellingJ.J Cell Mol Med,2017,21(5):1033-1041.36 ALEXANDER K A,RAGGATT L J,MILLARD S,et al.Resting and injury-induced inflamed periosteum containmultiple macrophage subsets that are located at sites ofbone growth and regenerationJ.Immunol Cell Biol,2017,95(1):7-16.37 RUYTINX P,PROOST P,VAN DAMME J,et al.Chemokine-inducedmacrophagepolarizationininflammatory conditionsJ.Front Immunol,2018,9:1930.38 ZHANG B,YIN Y,LAI R C,et al.Mesenchymal stemcells secrete immunologically active exosomesJ.StemCells Dev,2014,23(11):1233-1244.39 LO SICCO C,REVERBERI D,BALBI C,et al.Mesenchymal stem cell-derived extracellular vesicles asmediators of anti-inflammatory effects:endorsement ofmacrophage polarizationJ.Stem Cells Transl Med,2017,6(3):1018-1028.40 COSENZA S,RUIZ M,TOUPET K,et al.Mesenchymalstem cells derived exosomes and microparticles protectcartilage and bone from degradation in osteoarthritisJ.Sci Rep,2017,7(1):16214.41 MAHON O R,BROWE D C,GONZALEZ-FEMANDEZT,et al.Nano-particle mediated M2 macrophage polarizationenhances bone formation and MSC osteogenesis in an IL-10dependent mannerJ.Biomaterials,2020,239:119833.42 ZHANG S,CHUAH S J,LAI R C,et al.MSC exosomesmediatecartilagerepairbyenhancingproliferation,attenuating apoptosis and modulating immune reactivityJ.Biomaterials,2018,156:16-27.作者与读者“再生”是生物个体修复、替换受损或缺失的细胞和组织的过程，其在个体稳态调节和器官损伤修复中发挥了重要的作用。再生医学旨在开发和应用新的治疗方法，恢复组织和器官因衰老、疾病和损伤丧失的功能，已成为全球生命科学医学领域的前沿方向之一。当前，全球老龄化问题日趋严峻。据联合国世界人口展望2022的数据显示，预计2050年，全世界每6人中，就有1人年龄在65岁（16%）以上。与日俱增的老年人口为国家发展带来巨大挑战。衰老是疾病最大的危险因子，人体组织器官在衰老过程中出现干细胞耗竭、再生修复能力下降、功能衰退等现象，阿尔兹海默症、帕金森病、癌症等多种疾病发生率攀升。解析组织器官再生的规律和调控机制，挖掘再生相关的生物标志物及可能的干预靶点，以此发展调控再生、延缓器官衰老的可靠干预策略，具有重要的研究意义和应用前景。插图表达了运用再生医学手段逆转衰老时钟的寓意。破旧的“时钟”代表衰老，“壁虎”和“爬山虎”象征再生。“壁虎”象征衰老干预策略。这些元素结合起来象征领域发展生机勃勃。封面故事77