HainanMedJ,Jul.2023,Vol.34,No.13海南医学2023年7月第34卷第13期SARS-CoV-2相关血管紧张素转化酶2表达异常与乳腺疾病的关系研究新进展黄伟健1，曾达通1综述黄素宁2审校1.广西玉林市红十字会医院病理科，广西玉林537000；2.广西医科大学附属肿瘤医院放疗科，广西南宁530021【摘要】严重急性呼吸综合征冠状病毒-2(severeacuterespiratorysyndromecoronavirus-2，SARS-CoV-2)引起的新型冠状病毒感染目前全世界已有超过6亿4000万的确诊病例，其中血管紧张素转化酶2(ACE2)作为SARS-CoV-2入侵宿主细胞的最重要受体已经引起了广泛关注。ACE2在乳腺癌和乳腺炎中异常表达，并通过肾素-血管紧张素-醛固酮系统和炎症作用发挥作用。本文将对SARS-CoV-2造成的ACE2减少在乳腺癌和乳腺炎中的研究进展进行综述，旨在为预防SARS-CoV-2对乳腺的损害及ACE2与乳腺疾病发生的分子机制研究提供思路。【关键词】血管紧张素转化酶2；乳腺癌；乳腺炎；严重急性呼吸综合征冠状病毒-2；研究进展【中图分类号】R511【文献标识码】A【文章编号】1003—6350（2023）13—1963—04ResearchprogressontherelationshipbetweenabnormalexpressionofSARS-CoV-2-relatedangiotensin-con-vertingenzyme2andbreastdisease.HUANGWei-jian1,ZENGDa-tong1,HUANGSu-ning2.1.DepartmentofPathol-ogy,RedCrossHospitalofYulinCity,Yulin537000,Guangxi,CHINA;2.RadiotherapyTechnologyCenter,AffiliatedTumorHospitalofGuangxiMedicalUniversity,Nanning530021,Guangxi,CHINA【Abstract】Therearecurrentlymorethan640millionconfirmedcasesofnovelcoronavirusinfectioninducedbysevereacuterespiratorysyndromecoronavirus-2worldwide.Angiotensin-convertingenzyme2(ACE2),asthemostim-portantreceptorforSARS-CoV-2invasionintohostcells,hasgainedwidespreadattention.ACE2isaberrantlyex-pressedinbreastcancerandmastitis,andfunctionsthroughtherenin-angiotensin-aldosteronesystemandtheroleofin-flammation.Inthisarticle,wewillreviewtheresearchprogressinACE2reductioncausedbySARS-CoV-2inbreastcancerandmastitis,withthegoalofprovidinginsightsforthepreventionofSARS-CoV-2damagetothebreastandtheinvestigationofthemolecularmechanismsofACE2andmammarydiseasedevelopment.【Keywords】Angiotensin-convertingenzyme2;Breastcancer;Mastitis;SARS-CoV-2;Researchprogress·...
