综述DOI：10.11724/jdmu.2023.02.10纳米技术在骨关节炎疼痛治疗中的应用进展郭馨孺，栾永，宋辛叶（大连医科大学附属第一医院麻醉科，辽宁大连116011）[摘要]骨关节炎（osteoarthritis，OA）是导致中老年人疼痛、失能甚至引发心理疾病的主要原因之一，现有治疗方式均具有一定局限性，迫切需要新的诊断方法和镇痛方案。近年来，纳米技术在医学领域的应用已取得一定进展，应用纳米颗粒载药可同时发挥延长释放、按需释放、靶向释放药物等多重优势；利用纳米颗粒制成纳米探针还能够辅助OA的定位诊断及治疗。本文汇总并分析近年来纳米技术在OA疼痛治疗中的应用，分类评述纳米技术在药物递送、药物释放、诊疗方式等方面的最新进展，为OA的诊断和治疗提供新思路。[关键词]纳米技术；骨关节炎；疼痛；靶向治疗[中图分类号]R459.9[文献标志码]A文章编号：1671-7295(2023)02-0151-05Advancesofapplicationofnanotechnologyinthetreatmentofosteoarthritis-relatedpainGUOXinru,LUANYong,SONGXinye(DepartmentofAnesthesiology,theFirstAffiliatedHospitalofDalianMedicalUniversity,Dalian116011,China)[Abstract]Osteoarthritis(OA)isoneofthemaincausesofpain,disabilityandevenmentalillnessinmiddle-agedandelderlypopulation.Theexistingtreatmentmethodshavecertainlimitations,andnewdiagnosticmethodsandanalgesicprogramsareurgentlyneeded.Inrecentyears,theapplicationofnanotechnologyinthefieldofmedicinehasmadecertainprogresses.Thenanoparticledrugdeliverysystemhasmultipleadvantageswithaprolongedrelease,on-demandrelease,andtargetedreleaseofmedicine.Nanoprobesmadefromnanoparticlescanalsoassistinthelocalization,diagnosisandtreatmentofOA.ThispapersummarizesandanalyzestheapplicationofnanotechnologyinthetreatmentofOA-relatedpaininrecentyears,andsystemicallyreviewsthelatestprogressofnanotechnologyindrugdelivery,drugrelease,diagnosisandtreatment,soastoprovidenewideasforthediagnosisandtreatmentofOA.[Keywords]nanotechnology;osteoarthritis;pain;targetedtherapy骨关节炎（osteoarthritis，OA）是由于损伤或病变导致关节软骨退行性变和继发性骨质增生并累及整个关节的一种慢性关节疾病，以关节疼痛和活动受限为主要表现。OA可分为原发性和继发性两大类，原发性一般是由年龄增长、衰老退变导致；继发性则...
