多囊卵巢综合症诊治(zhěnzhì)进展浙江大学(zhèjiāndàxué)ɡ医学院附属妇产科医院第一页,共五十五页。第一页,共五十五页。授课(shòukè)提纲PCOS概念(gàiniàn)及相关进展PCOS发病机制及相关进展PCOS诊断标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展第二页,共五十五页。第二页,共五十五页。PCOS概念(gàiniàn)-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism(HA)polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003Rotterdamconsensusworkshop第三页,共五十五页。第三页,共五十五页。多囊卵巢(luǎncháo)综合症的概念-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223第四页,共五十五页。第四页,共五十五页。PCOS病理(bìnglǐ)生理特点-1AsyndromeofovariandysfunctionAlongwiththecardinalfeatureshyperandrogenism(HA)polycysticovary(PCO)morphology.Itsclinicalmanifestationsinclude:menstrualirregularities,signsofandrogenexcessandobesity.IRandelevatedserumLHlevelsarealsocommonfeatures.Associatedwithanincreasedriskoftype2diabetesandcardiovascularevents.The2003Rotterdamconsensusworkshop第五页,共五十五页。第五页,共五十五页。PCOS病理(bìnglǐ)生理特点-2Theconditionthathaveamajoreffectthroughoutlifeonthereproductive,metabolic,andcardiovascularhealth.SimplifiedbyEhrmannDAinNEnglJMed2005;352:1223第六页,共五十五页。第六页,共五十五页。授课(shòukè)提纲PCOS概念及相关进展PCOS发病机制及相关进展PCOS诊断(zhěnduàn)标准及相关进展PCOS鉴别诊断及相关进展PCOS治疗及相关进展第七页,共五十五页。第七页,共五十五页。PCOS发病机制及相关(xiāngguān)进展未完全阐明遗传学背景:相关基因多态性易感性!发育(fāyù)源性:表观遗传修饰/基因调控异常新!内分泌紊乱:下丘脑-垂体-卵巢轴功能/糖脂代谢紊乱经典/主流!第八页,共五十五页。第八页,共五...