高嗜酸性粒细胞综合症及嗜酸性粒细胞增多症：诊断要点(yàodiǎn)和治疗进展第一页，共二十三页。TefferiA,GotlibJ,PardananiA.Hypereosinophilicsyndromeandclonaleosinophilia:point-of-carediagnosticalgorithmandtreatmentupdate.MayoClinProc.2010;85(2):158-64.第二页，共二十三页。Acquiredeosinophilia•Acquiredeosinophiliaisoperationallycategorizedintosecondary,clonal,andidiopathictypes.•Causesofsecondaryeosinophiliaincludeparasiteinfections,allergicorvasculitisconditions,drugs,andlymphoma.•Clonaleosinophiliaisdistinguishedfromidiopathiceosinophiliabythepresenceofhistologic,cytogenetic,ormolecularevidenceofanunderlyingmyeloidmalignancy.第三页，共二十三页。获得性嗜酸性(suānxìnɡ)粒细胞增多症•获得性嗜酸性粒细胞增多症被人为的分为继发性,克隆性和特发性三种类型。•继发性嗜酸性粒细胞增多的原因包括：寄生虫感染、过敏或血管炎,药物和淋巴瘤。•克隆性嗜酸性粒细胞增多是区别于特发性嗜酸性粒细胞增多的，通过(tōngguò)组织学、细胞遗传学、或潜在的髓系恶性增生的分子证据。第四页，共二十三页。Clonaleosinophilia•TheWorldHealthOrganizationclassificationsystemforhematologicmalignanciesrecognizes2distinctsubcategoriesofclonaleosinophilia:chroniceosinophilicleukemia,nototherwisespecified(CEL-NOC)andmyeloid/lymphoidneoplasmswitheosinophiliaandmutationsinvolvingplatelet-derivedgrowthfactorreceptoralpha/beta(PDGFRAorPDGFRB)orfibroblastgrowthfactorreceptor1(FGFR1).第五页，共二十三页。克隆(kèlónɡ)性嗜酸性粒细胞增多症•世界卫生组织恶性血液病分类系统将克隆性嗜酸性粒细胞增多症分为2个不同(bùtónɡ)的亚型：未另行规定的慢性嗜酸性白血病和伴有血小板源生长因子受体α/β或纤维母细胞生长因子受体1基因突变的髓系/淋巴系肿瘤。第六页，共二十三页。Clonaleosinophilia•ClonaleosinophiliamightalsoaccompanyotherWorldHealthOrganization-definedmyeloidmalignancies,includingchronicmyelogenousleukemia,myelodysplasticsyndromes,chronicmyelomonocyticleukemia,andsystemicmastocytosis.第七页，共二十三页。克隆(kèlónɡ)性嗜酸性粒细胞增多症•克隆性嗜酸性粒细胞增多症也可能(kěnéng)伴发其他世界卫生组织定义的髓系恶性肿瘤,包括慢性粒...
