2022年医学专题—传染病Viral-hepatitis.pptVIP免费

1ViralhepatitisTianjinMedicalUniversityGeneralHospitalDepartmentofInfectiousDiseases逄崇杰第一页，共九十四页。第一页，共九十四页。2HBV形态、基因组结构和编码蛋白HBV、HCV的发病机制肝炎的临床(línchuán)ɡ分类和临床(línchuán)ɡ表现（慢肝和重肝）HBV抗原-抗体系统的组成和意义慢性HBV、HCV的治疗HBV的母婴阻断第二页，共九十四页。第二页，共九十四页。3定义：病毒性肝炎，Dane颗粒，慢性肝炎，窗口期，cccDNA，胆酶分离HBV在人体内的复制过程和发病机制(jīzhì)HCV感染易转为慢性的原因HBV抗原-抗体系统的组成和意义各型病毒性肝炎的传播途径病毒性肝炎的临床分类重型肝炎的并发症慢性乙肝、丙肝的药物治疗意外暴露HBV后的预防第三页，共九十四页。第三页，共九十四页。4ViralhepatitisisagroupsystemiccommunicablediseaseaffectingtheliverpredominantlycausedbysomekindsofvirusesViralhepatitismaybedividedinto5typesaccordingtoetiology,thatishepatitisA,B,C,DandEAlthoughtheagentscanbedistinguishedbyitsantigenicproperties,the5kindsofvirusesmayproduceclinicalsimilarillness第四页，共九十四页。第四页，共九十四页。5Clinicalmanifestationsarecharacterizedbyanorexia,nausea,fatigue,enlargedliverandabnormalliverfunction,apartofcasesmayappearjaundice.HepatitisAandEshowsacutehepatitis,fecal-oralroutepredominantlyHepatitisB,CandDpredisposetoachronichepatitisandisrelatedtolivercirrhosisandhepaticcancer,humoraltransmission.第五页，共九十四页。第五页，共九十四页。6Recently,3kindsofvirusesnamedGBV-C,TTVandSENVarediscovered,andnotyetconsideredtorelatetoviralhepatitis第六页，共九十四页。第六页，共九十四页。7HAVisonekindofpicornavirus（微小(wēixiǎo)RNA病毒科）andusedtobeclassifiedasenterovirustype72,butrecently,itisconsideredtobeclassifiedasheparnavirus（嗜肝RNA病毒属）HepatitisAvirionisasphericalparticle,diameter27~32nmConsistsofagenomeoflinear,single-strandedRNA,7.5kb第七页，共九十四页。第七页，共九十四页。8Sevengenetypes,1,2,3,4typesfromhumanbodyOnlyoneantigen-antibodysystem.Anti-HAVIgMisdiagnosticevidenceofrecentinfection,IgGisprotectiveantibody.Duringacutestageofinfe...