2023年5月第30卷第5期急性脑梗死患者rt-PA静脉溶栓治疗预后情况及相关影响因素分析冯陆,韩凯(焦作市人民医院神经内科三区,河南焦作454000)【摘要】目的探讨急性脑梗死患者阿替普酶(rt-PA)静脉溶栓治疗的预后情况,并分析其相关影响因素。方法将120例急性脑梗死患者随机分为对照组(60例)和观察组(60例)。对照组予以常规治疗,观察组在对照组基础上予以rt-PA静脉溶栓治疗,比较两组患者治疗后3个月的神经功能(NIHSS评分)、日常活动能力(BI评分)及预后情况(mRS评分)。根据mRS评分将观察组分为预后良好和预后不佳两个亚组,并通过单、多因素Logistic模型分析影响其预后的相关因素。结果治疗后3个月,观察组的NIHSS、mRS评分低于对照组,BI评分高于对照组(P<0.05)。观察组预后良好53例,预后不佳7例;经单因素和多因素Logistic分析显示,心脏疾病史、糖尿病、营养状况是影响观察组患者预后的独立因素(P<0.05)。结论rt-PA静脉溶栓治疗有利于急性脑梗死患者预后恢复,而心脏疾病史、糖尿病、营养不良会影响其预后情况。【关键词】rt-PA静脉溶栓;急性脑梗死;预后;影响因素中图分类号:R743.33文献标识码:Adoi:10.3969/j.issn.1674-4659.2023.05.0725AnalysisonPrognosisandRelatedInfluencingFactorsofrt-PAIntravenousThrombolysisinPatientswithAcuteCerebralInfarction//FENGLu,HANKai(3rdWardofNeurologyDepartment,JiaozuoPeople'sHospital,Jiaozuo454000,China)[Abstract]ObjectiveToexploretheprognosisofpatientswithacutecerebralinfarctionundergoingalteplase(rt-PA)intravenousthrombolysis,andanalyzetherelatedinfluencingfactors.Methods120patientswithacutecerebralinfarctionwererandomlydividedintocontrolgroup(60cases)andobservationgroup(60cases).Thecontrolgroupwasgivenroutinetreatment,andtheobservationgroupwastreatedwithrt-PAintravenousthrombolysisonthebasisofthecontrolgroup.Theneurologicalfunction(NIHSSscore),dailyactivityability(BIscore)andprognosis(mRSscore)at3monthsaftertreatmentwerecomparedbetweenthetwogroups.AccordingtothemRSscore,theobservationgroupwasdividedintotwosubgroups(goodprognosisandpoorprognosis),andtherelatedfactorsaffectingtheprognosiswereanalyzedbyunivariateandmultivariateLogisticmodel.Results3monthsaftertreatment,theNIHSSandmRSs...