ProductsofadipocyteswhichmayberelevanttotheProductsofadipocyteswhichmayberelevanttothepathophysiologyofthemetabolicsyndromepathophysiologyofthemetabolicsyndrome脂肪组织——新的内分泌器官脂肪组织——新的内分泌器官(qìguān)(qìguān)ResistinResistin(2001)(2001)AdiponectinAdiponectin(1991)(1991)Vitronectin(2000)Vitronectin(2000)PPARsOmentinOmentin(2003)(2003)第一页，共三十九页。病因病因(bìngyīn)(bìngyīn)//机理机理遗传因素遗传因素环境因素环境因素ACAC肥大肥大//增殖增殖AdipocytokinesAdipocytokinesTNF-TNF-α↑α↑NEFANEFA↑↑IL-6↑IL-6↑ResistinResistin↑↑PAI-1↑PAI-1↑AP↓AP↓第二页，共三十九页。VFVF(omentalF)(omentalF)↓↓apM1apM1OmentinOmentinMSMSIRIGT高血压血脂异常(yìcháng)DC,2003,26:2442第三页，共三十九页。AC/IRAC/IR新概念新概念(gàiniàn)(gàiniàn)ACAC致致mIRmIRACAC致致LLIRIRACAC致心肌致心肌IRIRACAC致胰致胰IRIRACAC致内皮致内皮IRIRACAC致致ACAC自身自身IRIR第四页，共三十九页。TNF-αTNF-α妨碍肌、脂妨碍肌、脂InsIns信号转导信号转导Glut4Glut4表达、转位↓表达、转位↓肌、脂肌、脂GG摄取↓糖原合成↓摄取↓糖原合成↓↑↑脂解，↑脂解，↑NEFANEFAAdipostatAdipostat，，TNF-α/leptin,TNF-α/leptin,限制限制ACAC体积增大体积增大促进细胞调亡，肿瘤恶病质有关促进细胞调亡，肿瘤恶病质有关↑↑IL-6IL-6第五页，共三十九页。IL-6IL-6，（来源，（来源(láiyuán)(láiyuán)MPMP，，LCLC，，ACAC））ThemostendocrineCKThemostendocrineCKTNF-α↑↑CRPCRPOB-lowgradeinflammatoryOB-lowgradeinflammatorystate→Asstate→AsHPAAXIS↑HPAAXIS↑ACACIL-6↑IL-6↑（一）（一）FF脂肝、脂脑对话脂肝、脂脑对话↑↑肝肝TGTG↑↑脂解脂解OOPPEE22（—）（—）（—）（—）第六页，共三十九页。Resistin(2001)Resistin(2001)ChCh1919（人）（人）仅于仅于WATWAT特异表达特异表达抗抗resistin-Abresistin-Ab处理处理(chǔlǐ)(chǔlǐ)，，In-Med-GIn-Med-G摄取↑摄取↑,,BG↓BG↓TZDTZD（（PPAR-γPPAR-γ配基）下调配基）下调resistinresistin第七页，共三十九页。肥胖肥胖(féipàng)(féipàng)——Resistin——DM2——Resistin——DM2SI↓SI↓IGTIGTDM2DM2第八页，共三十九页。肥胖肥胖(féipàng)(féipàng)——Resistin——DM2——Resistin——DM2SI↓SI↓I...
