第六篇血液(xuèyè)系统疾病第九章白血病(Leukemia)周剑峰学时(xuéshí)数：3学时(xuéshí)第一页，共七十二页。讲授目的(mùdì)和要求1.掌握急、慢性白血病的临床表现，实验室检查及诊断标准，治疗原则。2.熟悉急性(jíxìng)白血病FAB分型，联合化疗的原则，完全缓解的概念。第二页，共七十二页。讲授(jiǎngshòu)主要内容概述(àishù)ɡ病因和发病机制临床表现实验室检查诊断标准鉴别诊断治疗第三页，共七十二页。概述第四页，共七十二页。Erythrocytes:transportoxygenErythrocytes:transportoxygenNeutrophilBasophilEosinophilMonocytes/MacrophageDefenseagainstinfectionDefenseagainstinfectionPlatelets:MediatebloodclottingPlatelets:MediatebloodclottingT-lymphocytes:antigenpresentingT-lymphocytes:antigenpresentingB-lymphocytesB-lymphocytesPlasmacell:Plasmacell:SourceofantibodiesSourceofantibodies第五页，共七十二页。PluripotentialstemcellsPluripotentialstemcellsMyeloidstemcellsMyeloidstemcellsLymphoidstemcellsLymphoidstemcellsUnipotentialprogenitorcellsUnipotentialprogenitorcellsImmaturehematopoieticcellsImmaturehematopoieticcellsmaturehematopoieticcellsmaturehematopoieticcells第六页，共七十二页。HematopoiesiscomposesoftheoptionsofcommitmenttodifferentlineagesHematopoiesiscomposesoftheoptionsofcommitmenttodifferentlineagesandtheprogressivestagesofmaturationatwhichpartialorcompleteandtheprogressivestagesofmaturationatwhichpartialorcompletearrestcanoccur,resultsinthewidearrayofmalignantdisease-Leukemia.arrestcanoccur,resultsinthewidearrayofmalignantdisease-Leukemia.StemcellProgenitorcellImmaturecellMaturecell第七页，共七十二页。AccumulationofmutationsofDNAwithinapluripotentialstemcellorveryearlyprogenitorcellgivesrisetoleukemicstemcells.NormalstemcellLeukemicstemcell第八页，共七十二页。第九页，共七十二页。第十页，共七十二页。病因和发病(fābìng)机制第十一页，共七十二页。Etiology&PathogenesisEnvironmentalfactorsAcquireddiseasesLesionstotheDNAClonalexpansion第十二页，共七十二页。Alotofenvironmentalfactorshasbeenreportedtocauseleukemia.Alotofenvironmentalfactorshasbeenreportedtocauseleukemia.However,on...
