EndometralCa1子宫内膜增生与子宫内膜癌前病变河北医大二院左宏玲第一页，共一百二十六页。EndometralCa2正常子宫内膜周期性再生、分化、剥脱，依赖女性激素作用。无排卵、排卵不规那么妇女因雌激素刺激，子宫内膜持续增生与长期受雌激素刺激、缺乏孕激素有关:单用雌激素一年，20%子宫内膜增生；以腺体病变为主、伴有少量间质病变，少数内膜增生可以开展成癌第二页，共一百二十六页。EndometralCa3国际妇科病理协会分期(ISGP,1987)〔InternationalSocietyofGynecologyPathology〕单纯增生〔simplehyperplasia〕良性病变,原腺囊性增生〔cysitichyperplasia〕复合增生〔complexhyperplasia〕良性病变原腺瘤性增生〔adenomatoushyperplasia)非典型增生〔atypicalhyperplasia〕癌前病变第三页，共一百二十六页。EndometralCa4Thisisthemicroscopicappearanceofnormalproliferativeendometriuminthemenstrualcycle.Theproliferativephaseisthevariablepartofthecycle.Inthisphase,tubularglandswithcolumnarcellsandsurroundingdensestromaareproliferatingtobuilduptheendometriumfollowingsheddingwithpreviousmenstruation.Hereisearlysecretoryendometrium.Theappearancewithprominentsubnuclearvacuolesincellsformingtheglandsisconsistentwithpost-ovulatoryday2.Thehistologicchangesfollowingovulationarequiteconstantoverthe14daystomenstruationandcanbeutilizedtodatetheendometrium.(proliferativeendometrium)(earlysecretoryendometrium)第四页，共一百二十六页。EndometralCa5Thisisnormalsecretoryphaseendometrium.Notethelargertortuousglandswithsecretions.Thesecretoryphasefollowsaset14daycourseleadingtoeitherimplantationofafertilizedovumormenstruation.第五页，共一百二十六页。EndometralCa6单纯增生〔simplehyperplasia〕子宫内膜腺体和间质增生,腺体不规那么，可扩张呈囊性并有群集间质致密无细胞异型性第六页，共一百二十六页。EndometralCa7复合增生〔complexhyperplasia〕腺体高度增生，成芽状或乳头状，腺体不规那么，呈现结构复杂和背靠背的群集，细胞呈复层或假复层无细胞异型性第七页，共一百二十六页。EndometralCa8细胞极性消失，大小不一，核深染，腺上皮细胞异行型；无间质浸润。根据腺上皮增生程度分为轻、中、重。第八页，共一百二十六页。EndometralCa9Thisisendometrialcystichyperplasiainwhichtheam...
