骨肉瘤新辅助化疗后CT值的变化与预后关系的相关性研究王帅1,郑凯2,徐明2,于秀淳21.山东中医药大学第一临床医学院山东济南250355;2.中国人民解放军第九六〇医院骨科山东济南250031【摘要】目的探讨骨肉瘤新辅助化疗后CT值的变化与预后的相关性。方法选取19例原发性骨肉瘤患者的CT及临床资料,测量患者新辅助化疗前后肿瘤病灶的平均CT值(HUmean),并计算HUmean变化率,计算公式为:HUmean变化率=(HUmean化疗后-HUmean化疗前)/HUmean化疗前。根据患者实际治疗结果分成预后良好组及预后不良组,用非参数检验比较两组HUmean变化率。结果预后良好组12例,预后不良组7例。全部患者新辅助化疗后HUmean为387.67(276.95)HU,较化疗前315.39(236.82)HU明显升高,差异具有统计学意义(Z=-2.455,P=0.014)。预后良好组HUmean变化率13.15(30.14)×100%明显高于预后不良组-4.57(7.78)×100%,差异具有统计学意义(Z=-3.550,P<0.001)。结论骨肉瘤新辅助化疗后CT值的变化与预后相关,化疗后肿瘤CT值明显增加,变化率高提示预后良好。可以通过新辅助化疗前后CT值的变化来评估骨肉瘤患者预后。【关键词】骨肉瘤;新辅助化疗;体层摄影术,X线计算机;预后中图分类号:R738.1;R814.42文献标识码:A文章编号:1006-9011(2023)04-0623-04AstudyonthecorrelationbetweenchangesinCTvaluesandprognosisafterneoadjuvantchemotherapyforosteosarco-maWANGShuai1,ZHENGKai2,XUMing2,YUXiuchun21.TheFirstClinicalMedicalCollege,ShandongUniversityofTraditionalChineseMedicine,Jinan250355,China2.DepartmentofOsteology,The960thHospitalofPLA,Jinan250031,China【Abstract】ObjectiveToexplorethecorrelationbetweenthechangeofCTvalueandprognosisafterneoadjuvantchemothera-pyforosteosarcoma.MethodsWeretrospectivelyanalyzedtheCTandclinicaldataof19patientswithprimaryosteosarcomaconfirmedbypathology,measuredtheaverageCTvalue(HUmean)oftumorlesionsbeforeandafterneoadjuvantchemotherapy,andcalculatedtherateofchangeofHUmeanbyuseofthefollowingformula:HUmeanrateofchange=(HUmeanchemotherapy-beforeHUmeanchemotherapy)/beforeHUmeanchemotherapy.Accordingtotheactualtreatmentresultsofthepatients,theyweredividedintoagroupwithagoodprognosisandapoorprognosisgroup,andtherateofchangeofHUmeanbetweenthetwogrou...