·临床研究·高原患者髋关节置换术后谵妄的危险因素分析叶晓莉尚凯茜孙琪荣李卓柠夏宗敬王辉DOI:10.12089/jca.2023.02.011基金项目:西藏自治区自然科学基金项目(XZ202001ZR0045G,XZ202101ZR0049G)作者单位:610041成都市,西藏自治区人民政府驻成都办事处医院四川大学华西医院西藏成办分院麻醉科(叶晓莉、尚凯茜、李卓柠、夏宗敬、王辉);四川大学华西医院麻醉手术中心(孙琪荣)通信作者:尚凯茜,Email:shang_2310@163.com【摘要】目的探讨全麻下行髋关节置换术的高原患者发生术后谵妄(POD)的危险因素。方法选择择期行全麻髋关节置换术的高原患者1010例,男373例,女637例,年龄24~76岁,BMI19.0~34.7kg/m2,ASAⅠ—Ⅲ级。根据术后7d内是否发生谵妄分为两组:POD组和非POD组,采用多因素Logistic回归分析确定行髋关节置换术的高原患者发生POD的相关危险因素。结果术后7d内有120例(11.9%)患者发生POD。多因素Logistic回归分析显示,年龄(每增加10岁,OR=2.106,95%CI1.616~2.745,P<0.001)、脑梗死病史(OR=9.712,95%CI3.620~26.055,P<0.001)、术后中重度疼痛(OR=6.826,95%CI2.991~15.578,P<0.001)以及常居海拔高度3500~4500m(OR=2.844,95%CI1.448~5.587,P=0.002)和高原红细胞增多症(OR=5.374,95%CI3.900~7.404,P<0.001)是发生POD的危险因素。结论年龄、脑梗死病史、术后中重度疼痛以及常居海拔高度3500~4500m和高原红细胞增多症是高原患者全麻下髋关节置换发生POD的危险因素。【关键词】高原;危险因素;术后谵妄;髋关节置换术;全身麻醉RiskfactorsofpostoperativedeliriuminpatientsfromhighaltitudeundergoingtotalhiparthroplastyYEXiaoli,SHANGKaixi,SUNQirong,LIZhuoning,XIAZongjing,WANGHui.De-partmentofAnesthesiology,HospitalofChengduOfficeofPeople’sGovernmentofTibetanAutonomousRegion&WestChinaHospitalSichuanuniversityTibetChengduBranchHospital,Chengdu610041,ChinaCorrespondingauthor:SHANGKaixi,Email:shang_2310@163.com【Abstract】ObjectiveToevaluatetheriskfactorsofpostoperativedelirium(POD)inpatientsfromhighaltitudeundergoingtotalhiparthroplasty.MethodsAtotalof1010patientsundergoingelectivegeneralanesthesiafortotalhiparthroplasty,373malesand637females,aged24-76years,BMI19.0-34.7kg/m2,ASAphysicalstatusⅠ—Ⅲ,wereretrospectivelyanalyzed...