2022年医学专题—甲状腺激素和抗甲状腺药Thyroid(1).pptVIP免费

甲状腺激素(jīsù)和抗甲状腺药Thyroidhormonesandantithyroiddrugs北京(běijīnɡ)协和医学院基础医学院药理学系叶菜英第一页，共三十四页。SummaryThyroidhormones第二页，共三十四页。ThyroidhormonesThyroxine,T4第三页，共三十四页。抗甲状腺药分为4类：硫脲类Thiourea第四页，共三十四页。硫脲类硫氧嘧啶类（thiouracil）：•甲基硫氧嘧啶（methykthiouracil）第五页，共三十四页。ThyroidhormonesareiodicaminoacidsThyroidhormones第六页，共三十四页。甲状腺激素(jīsù)的化学结构第七页，共三十四页。Physiologicaldispositionofthyroidhormones第八页，共三十四页。Synthesis,storageandregulationofthyroidhormonesIodineuptakeIodineactivationandtyrosineiodation第九页，共三十四页。Stepsofthyroidhormonessynthesis,releaseandregulation()ⅠIinbloodcanbeuptakenintocellsbyiodinepumpintheadenocytemembrane.Theaminoacidscanbeusedtosynthesizethyroidglobulinincells.第十页，共三十四页。Condensationandstorage:Inthethyroidglobulinmolecule,twoDTTsarecondensedtoT4,oneDTTandoneMITarecondensedtoT3，whichareallstoredinglandalveoluscolloid.Stepsofthyroidhormonessynthesis,releaseandregulation()Ⅱ第十一页，共三十四页。Synthesis,storageandreleaseofthyroidhormoneGastrointestinalI-GastrointestinalI-BloodI-BloodI-I-I-PeroxidaseIoIoTGTGTyrIodationMITMITDITDITCon-den-sationMIT+DITDIT+DITT3T3T4T4TGTGAcinarluminaStorageSynthesisReleaseActivationProteaseT3T3T4T4MIT一碘酪氨酸DIT二碘酪氨酸TG甲状腺球蛋白bloodblood第十二页，共三十四页。ThyroidhormonesMechanismofaction第十三页，共三十四页。Mechanismofaction（figure)Thyroidhormones第十四页，共三十四页。PhysiologicalandpharmacologicalactionsKeepnormalgrowthanddevelopment第十五页，共三十四页。ThyroidclinicalapplicationReplacementtherapymainlyTherapyanddiagnosisApplication第十六页，共三十四页。AdverseeffectsAdverseeffectOverdoseCombinationContraindicationhyperthyreosisoldpeopleheartdiseasebishydroxycoumarindantinaoraspirindiabeteshypertensionCoronaryheartdiseasepyknocardiathyroidcrisis:anxiety,fear,restlessness,highbodytemperature,increaseandirregularheartrate,increase...