25第35卷第1期2023年VOL.35NO.12023菏泽医学专科学校学报JOURNALOFHEZEMEDICALCOLLEGEDOI:10.3969/j.issn.1008-4118.2023.01.007肺癌患者术后放疗相关肺毒性的影响因素研究卢衍毅（定陶区人民医院，山东菏泽274199）摘要：目的探讨肺癌患者术后放疗发生放疗相关肺毒性（RILT）的影响因素。方法选择我院肺癌术后经放射治疗的患者86例，其中发生RILT患者25例，设置为观察组，未发生RILT患者61例设置为对照组，采用Logistic回归分析肺癌术后RILT产生的危险因素。结果观察组患者年龄>60岁、伴有肺部慢性疾病占比高于对照组（P<0.05）；观察组放疗剂量>50Gy、照射剂量5Gy的肺组织占全肺总体积的百分比（V5）>45%、照射剂量20Gy的肺组织占全肺总体积的百分比（V20）>23%、平均肺剂量（MLD）>10Gy、同期化疗占比高于对照组（P<0.05）。结论年龄>60岁、合并肺部慢性疾病、放疗剂量>50Gy、V5>45%、V20>23%、MLD>10Gy、同期化疗为肺癌术后放疗发生RILT的独立危险因素。关键词：肺癌；放疗相关肺毒性；危险因素中图分类号：R734.2文献标识码：A文章编号：1008-4118（2023）01-0025-04ResearchontheinfluencefactorsofpostoperativeradiotherapyrelatedtoxicityinpatientswithlungcancerLUYanyi(DingtaoDistrictPeople’sHospitalofHeze,Heze274199,Shandong)Abstract:ObjectiveToexploretheinfluencefactorsofpostoperativeradiotherapyrelatedtoxicityinpatientswithlungcancer.MethodsThisresearchcollatedandanalyzedthedataof86patientswithlungcancerwhoreceivedpostoperativeradiotherapyinthehospital.Twenty-fivepatientswithradiation-inducedlungtoxicity(RILT)wereincludedintheobservationgroup,andsixty-onepatientswithoutRILTwereincludedinthecontrolgroup.RiskfactorsinfluencingtheoccurrenceofRILTwereanalyzedbylogisticregression.ResultsThepercentagesofpatientsagedover60yearsorwithchronicpulmonarydiseasesintheobservationgroupweresignificantlyhigherthanthoseofinthecontrolgroup(P<0.05).Thepercentageoflungtissuewithradiotherapydose>50Gyandirradiationdose>5Gyintotallungvolume(V5)>45%,thepercentageoflungtissuewithirradiationdoseof20Gyintotallungvolume(V20)>23%,meanlungdose(MLD)>10Gyandconcurrentchemotherapyintheobservationgroupweresignificantlyhigherthanthoseofthecontrolgroup.ConclusionAgeover60ye...
