念珠菌流行病学(liúxínbìnxué)ɡɡ趋势与IDSA2009年念珠菌治疗指南江苏省人民(rénmín)医院周苏明2011年2月27日EpidemiologyofcandidemiainintensivecareunitsInternationalJournalofAntimicrobialAgents32Suppl.2(2008)S87–S91AgrowingproportionofepisodesofcandidemiahavebeencausedbyCandidaspeciesotherthanalbicans.•Epidemiology,management,andriskfactorsfordeathofinvasiveCandidainfectionsincriticalcare:Amulticenter,prospective,observationalstudyinFrance(2005–2006)(CritCareMed2009;37:1612–1618)•OnehundredeightyICUsinFrance.•BetweenOctober2005andMay2006,300adultpatientswithproveninvasiveCandidainfection.•107(39.5%)patientswithisolatedcandidemia,•87(32.1%)withinvasivecandidiasiswithoutdocumentedcandidemia,•77(28.4%)withinvasivecandidiasisandcandidemia.•In37%ofthecases,candidemiaoccurredwithinthefirst5daysafterICUadmission.ConsensusstatementonthemanagementofinvasivecandidiasisinIntensiveCareUnitsintheAsia-PacificRegionInternationalJournalofAntimicrobialAgents34(2009)205–209中国5所医院念珠菌属对氟康唑和伏立康唑的耐药性监测ARTEMIS朱德妹张婴元汪复中国感染与化疗(huàliáo)杂志，2007,7(1):14~18•8000株念珠菌和酵母菌分别来自北京(běijīnɡ)、杭州、广州和上海5所三级甲等医院临床微生物实验室和真菌室临床分离株•CandidaAlbicansVersusNon-AlbicansIntensiveCareUnit-AcquiredBloodstreamInfections:DifferencesinRiskFactorsandOutcomeANESTHESIA&ANALGESIAVol.106,No.2,February200801/26/25InvasivecandidiasisintheintensivecareunitLuisOstrosky-Zeichner,CritCareMed2006;34:857–863危险(wēixiǎn)因素•ThemostimportantindependentconditionspredisposingtocandidemiainICUpatientsinclude:priorabdominalsurgery,intravascularcatheters,acuterenalfailure,parenteralnutrition,broad-spectrumantibiotics,aprolongedICUstay,theuseofcorticosteroidsandmucosalcolonizationwithCandida.InternationalJournalofAntimicrobialAgents32Suppl.2(2008)S87–S91ANESTHESIA&ANALGESIAVol.106,No.2,February2008MolecularbasisofresistancetoazoleantifungalsTRENDSinMolecularMedicineVol.8No.2February20021.唑类药物在细胞内的浓度降低(jiàngdī...
