(dònglì)CancerTherapy:PHOTODYNAMICTHERAPY徐克成徐克成广州复大肿瘤医院广州复大肿瘤医院FUDACANCERHOSPITALOFFUDACANCERHOSPITALOFGUANGZHOUGUANGZHOU中国中国(zhōnɡɡuó)(zhōnɡɡuó)广广州州GuangzhouCHINAGuangzhouCHINA第一页,共七十四页。第一页,共七十四页。第二页,共七十四页。第二页,共七十四页。是(jīběn)•直接杀伤肿瘤细胞•微血管损伤与循环障碍(zhàngài)—缺血与缺氧•免疫反应局部作用与全身反应短期效应与长期影响第三页,共七十四页。第三页,共七十四页。Combinationof3-effectsCombinationof3-effectsScientifictherapyScientifictherapy第四页,共七十四页。第四页,共七十四页。美国、欧洲、日本和加拿大批准―――•食管癌(部分或完全梗阻)(改善率90%)•早期食管癌的根治(治愈率95%-100%)•早期肺癌(气管、支气管癌)的根治(治愈率90%)•梗阻性肺癌(气管或支气管癌)(改善率85%)•表浅性胃癌(治愈率95%)•早期宫颈癌和化生性增生(治愈率96%)研究证明有良好效果•Barrett食管伴高度(gāodù)不典型增生,食管腺癌临床报告有效•早期口腔癌、头颈部肿瘤、脑瘤(胶质瘤)、胸膜或腹膜间皮瘤、腹腔肉瘤、眼肿瘤、鼻咽癌、胸壁肿瘤、妇科癌肿、直肠癌、胆管癌、Kaposi肉瘤、皮肤癌。第五页,共七十四页。第五页,共七十四页。第六页,共七十四页。第六页,共七十四页。PhotoactivationPhotoactivationPhotoactivationPhotoactivation630nmlaser630nmlaser630nmlaser630nmlaserFiberopticFiberopticFiberopticFiberoptic630nm630nm(nonthermal(nonthermal))630nm630nm(nonthermal(nonthermal))Optional2ndlaserapplicationOptional2ndlaserapplication96-120hourspostinjection96-120hourspostinjectionOptional2ndlaserapplicationOptional2ndlaserapplication96-120hourspostinjection96-120hourspostinjectionPhotodynamicPhotodynamicreactionkillscellsreactionkillscellsPhotodynamicPhotodynamicreactionkillscellsreactionkillscellsRelativelyRelativelyselectiveselectiveretentionofretentionofPHOTOFRINPHOTOFRIN®®intumorcellsintumorcells40-50hours40-50hourspostinjectionpostinjectionRelativelyRelativelyselectiveselectiveretentionofretentionofPHOTOFRINPHOTOFRIN®®intumorcellsintumorcells40-50hours40-50hourspostinjectionpostinjection第七页,共七十四页。第七...