冠心病英文版.pptxVIP免费

Atherosclerosis&CoronaryheartdiseasesZhengzhouUniversity,FirstaffiliatedHospitalDept.ofCardiologyHaiyuLi,M.D.第一页，共一百一十五页。CardiovascularDiseases第二页，共一百一十五页。Atherosclerosis第三页，共一百一十五页。•leadingcauseofdeathanddisability•Commonlocation:Coronarycirculation:Proximalleftanteriordescendingcoronaryartery(LAD)ProximalportionofrenalarteriesExtracranialcirculationtothebrainCarotidbifurcationAtherosclerosis第四页，共一百一十五页。CoronaryheartdiseaseatherosclerosisCoronarystenosiscoronaryspasmMyocardialischemia,anoxaemiaCoronaryheartdisease,CHDIschemicheartdisease第五页，共一百一十五页。•Atherosclerosis•Stableanginapectoris(SAP)•AcutecoronarysyndromeUnstableangina(UAP)andnon-STEMI(UA/NSTEMI)STelevationmyocardialinfarction(STEMI)第六页，共一百一十五页。Threefundamentalbiologicalprocessesofatherosclerosis1.Accumulationofintimalcells:•smoothmusclecells•Macrophages•T-lymphocytes2.Proliferatedconnectivetissuematrix:•collagen•elasticfibers•proteoglycans3.Accumulationoflipid:•cholesterolesters•freecholesterol第七页，共一百一十五页。PathologyandpathophysiologyFattysteakFibrousplaqueComplicatedlesionAtherosclerosis第十页，共一百一十五页。InitiationofAtherosclerosisFattysteakformation第十一页，共一百一十五页。InitiationofAtherosclerosisFattysteakformationLipoproteinoxidationNonenzymaticglycationLeukocyterecruitmentFoamcellformation第十二页，共一百一十五页。Atheromaevolution:fibrousplaqueAtheromaevolutionandcomplicationsVascularremodeling:compensatoryenlargement第十三页，共一百一十五页。Atheromaevolution:Involvementofarterialsmooth-musclecellsBloodcoagulationmicrovesselsAtheromaevolutionandcomplications第十四页，共一百一十五页。炎症细胞少量平滑肌细胞激活的巨噬细胞血栓Complicatedlesion:thrombosisAtheromaevolutionandcomplications第十五页，共一百一十五页。AtheromaevolutionandcomplicationsVulnerableplaque:ThinfibrouscapRelativelylargelipidcoreHighcontentofmacrophagesInflammatorymediators第十六页，共一百一十五...