2022年医学专题—肝细胞癌中表达-南京医科大学综述(1).ppt

The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma,徐 智南京医科大学附属南京第一医院暨南京市第一医院 肿瘤(zhngli)内科,1,第一页，共十四页。,Worldwide incidence of HCC,Blum HE,Spangenberg HC.Arch Iran Med.2007 Jul;10(3):361-71.,第二页，共十四页。,Identification of Yes-associated Protein(YAP),Zender,L.et al.Cell 125,1253-67,E,F,G,H,第三页，共十四页。,YAP improves cell proliferation,Time(Days),*：p0.05。,第四页，共十四页。,YAP induces anchorage-independent growth,MIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.,第五页，共十四页。,MIHA-YAP cells gained advantages in cell migration and invasion.,YAP enhances cellular mobility and invasiveness,第六页，共十四页。,IHC results of YAP in HCC,53.7%HCC samples showed nuclear YAP positive.,第七页，共十四页。,Clinical association of nuclear YAP in HCC,第八页，共十四页。,Clinical association of nuclear YAP and HCC-specific postsurgical recurrence,Kaplan-Meier,Median RFT：Nuclear YAP negative:25.8 months vs.Nuclear YAP positive：12.9 months,第九页，共十四页。,Nuclear YAP is an independent prognostic marker for HCC recurrence,Cox Regression,第十页，共十四页。,Summary,YAP confers tumorigenic and metastatic potentials in hepatocytes,as evidenced by enhanced aptitudes in cell viability,anchorage-independent growth,migration and invasion.YAP nuclear accumulation was found in the 53.7%of HCC,correlated with poorer tumor differentiation and higher serum alpha-fetoprotein(AFP)levels.Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival.YAP plays an important role in HCC development and progression.,第十一页，共十四页。,Acknowledgement,新加坡国立大学外科系和药学系 Asso.Prof.John M.Luk香港大学外科系 Prof.Fan S.T.，Prof.Poon R.T.and Surgical Tissue Bank南京市第一医院肿瘤(zhngli)内科,第十二页，共十四页。,Thank You,第十三页，共十四页。,内容(nirng)总结,The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma。Identification of Yes-associated Protein(YAP)。Zender,L.et al.Cell 125,1253-67。Thank You,第十四页，共十四页。,