TheClinicalSignificanceofNuclearYAPExpressioninHepatocellularCarcinoma徐智南京医科大学附属南京第一医院暨南京市第一医院肿瘤(zhǒngliú)内科1第一页，共十四页。WorldwideincidenceofHCCBlumHE,SpangenbergHC.ArchIranMed.2007Jul;10(3):361-71.第二页，共十四页。IdentificationofYes-associatedProtein(YAP)Zender,L.etal.Cell125,1253-67EFGH第三页，共十四页。YAPimprovescellproliferationTime(Days)*：p<0.05。第四页，共十四页。YAPinducesanchorage-independentgrowthMIHA-YAPcellsbutnotMIHA-Veccouldfo第五页，共十四页。MIHA-YAPcellsgainedadvantagesincellmigrationandinvasion.YAPenhancescellularmobilityandinvasiveness第六页，共十四页。IHCresultsofYAPinHCC53.7%HCCsamplesshowednuclearYAPpositive.第七页，共十四页。ClinicalassociationofnuclearYAPinHCC第八页，共十四页。ClinicalassociationofnuclearYAPandHCC-specificpostsurgicalrecurrenceKaplan-MeierMedianRFT：NuclearYAPnegative:25.8monthsvs.NuclearYAPpositive：12.9months第九页，共十四页。NuclearYAPisanindependentprognosticmarkerforHCCrecurrenceCoxRegression第十页，共十四页。Summary•YAPconferstumorigenicandmetastaticpotentialsinhepatocytes,asevidencedbyenhancedaptitudesincellviability,anchorage-independentgrowth,migrationandinvasion.•YAPnuclearaccumulationwasfoundinthe53.7%ofHCC,correlatedwithpoorertumordifferentiationandhigherserumalpha-fetoprotein(AFP)levels.•NuclearYAPisanindependentpredictorforHCC-specificrecurrence-freesurvival.•YAPplaysanimportantroleinHCCdevelopmentandprogression.第十一页，共十四页。Acknowledgement新加坡国立大学外科系和药学系Asso.Prof.JohnM.Luk香港大学外科系Prof.FanS.T.，Prof.PoonR.T.andSurgicalTissueBank南京市第一医院肿瘤(zhǒngliú)内科第十二页，共十四页。第十三页，共十四页。内容(nèiróng)总结TheClinicalSignificanceofNuclearYAPExpressioninHepatocellularCarcinoma。IdentificationofYes-associatedProtein(YAP)。Zender,L.etal.Cell125,1253-67。ThankYou第十四页，共十四页。
