[基金项目]秦皇岛市市级科技计划自筹项目(编号:201902A103)丁苯酞联合阿托伐他汀治疗急性脑梗死临床疗效分析范丽丽,佟亚男,金凤,陈蕊,孙鲁生,陈锦荣,傅艳芬,张淑丽(河北省秦皇岛市第一医院,河北秦皇岛066000)[摘要]目的分析丁苯酞联合阿托伐他汀治疗急性脑梗死(ACI)临床疗效。方法选取2021年1~12月在我院就诊的101例ACI患者,依照治疗药物不同分为对照组(n=48,常规手段)和研究组(n=53,丁苯酞联合阿托伐他汀),观察比较两组临床疗效。结果与治疗前比较,两组5-羟色胺、谷氨酸、多巴胺水平均上升,研究组各指标水平均高于对照组(P<0.05);两组侧支循环血流各项指标均有所改善,研究组改善程度优于对照组(P<0.05)。结论针对ACI患者应用丁苯酞联合阿托伐他汀治疗能够充分提升治疗效果,还可改善侧支血液循环,且用药安全,值得临床推广应用。[关键词]丁苯酞;阿托伐他汀;急性脑梗死;临床疗效;神经递质;侧支循环血流[中图分类号]R743.33[文献标志码]A[文章编号]1672-6170(2023)03-0118-04ClinicalefficacyanalysisofbutylphthalidecombinedwithatorvastatininthetreatmentofacutecerebralinfarctionFANLi鄄li,TONGYa鄄nan,JINFeng,CHENRui,SUNLu鄄sheng,CHENJin鄄rong,FUYan鄄fen,ZHANGShu鄄li(QinhuangdaoFirstHospital,Qinhuangdao066000,China)[Abstract]ObjectiveToanalyzetheclinicalefficacyofbutylphthalidecombinedwithatorvastatininthetreatmentofacutecerebralinfarction(ACI).MethodsOnehundredandonepatientswithACItreatedinourhospitalfromJanuary2021toDecember2021wereselected.Accordingtodifferentdrugs,thepatientsweredividedintoacontrolgroup(n=48treatedwithconventionalmeans)andastudygroup(n=53treatedwithbutylphthalidecombinedwithatorvastatin).Theclinicalefficacywascomparedbetweenthetwogroups.ResultsComparedwithbeforetreatment,thelevelsofserotonin,glutamateanddopamineinbothgroupswereincreased,andtheincreasedlevelsinthestudygroupwerehigherthanthoseinthecontrolgroup(P<0.05).Allindexesofcollateralbloodflowinthetwogroupswereimproved,andthedegreeofimprovementinthestudygroupwasbetterthanthatinthecontrolgroup(P<0.05).ConclusionsForpatientswithACI,theapplicationofbutylphthalidecombinedwithatorvastatincanfullyenhancethetherapeuticeffectandimprovethecollateralbloodcirculation.Thedrugsares...
