第41卷第2期2023年4月广东医科大学学报JOURNALOFGUANGDONGMEDICALUNIVERSITYVol.41No.2Apr.2023137WNT2B与肿瘤免疫浸润及患者预后的相关性樊馨竹1,2,3，沈艺琳1,2,3，许涛1,2,3，罗驰恒1,2,3，高羽亭1,2,3（1.广东医科大学公共卫生学院，广东东莞523808；2.东莞市环境医学重点实验室，广东东莞523808；3.东莞市环境与健康研究所，广东东莞523808）摘要：目的探讨WNT2B表达与肿瘤免疫浸润及患者预后的相关性。方法癌症患者WNT2B表达的原始数据来自癌症基因组图谱（TCGA）和基因型-组织表达（GTEx）数据库。分析WNT2B表达与预后、肿瘤免疫浸润、肿瘤新抗原、肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）之间的相关性。结果在正常组织和肿瘤组织中WNT2B的表达存在显著差异；WNT2B与癌症患者的预后、癌相关成纤维细胞浸润、免疫浸润细胞、肿瘤新抗原、TMB和MSI相关。结论WNT2B可能作为肿瘤免疫浸润和预后不良的生物标志物，为癌症的治疗提供了新靶点。关键词：WNT2B；癌症；免疫浸润；生物标志物中图分类号：R730.4文献标志码：A文章编号：2096-3610（2023）02-0137-08CorrelationbetweenWNT2BexpressionandtumorimmunoinfiltrationandprognosisFANXin-zhu1,2,3,SHENYi-lin1,2,3,XUTao1,2,3,LUOChi-heng1,2,3,GAOYu-ting1,2,3(1.SchoolofPublicHealth,GuangdongMedicalUniversity,Dongguan523808,China;2.DongguanKeyLaboratoryofEnvironmentalMedicine,Dongguan523808,China;3.DepartmentofEnvironmentalandOccupationalHealth,Dongguan523808,China)Abstract:ObjectiveToinvestigatethecorrelationbetweenWNT2Bexpressionandtumorimmunoinfiltrationandprognosis.MethodsRawdataofWNT2BexpressionincancerpatientswereobtainedfromtheCancerGenomeAtlas(TCGA)andGenotype-TissueExpression(GTEx)databases.ThecorrelationbetweenWNT2Bexpressionandprognosis,tumorimmunoinfiltration,tumorneoantigens,tumormutationload(TMB)andmicrosatelliteinstability(MSI)wasanalyzed.ResultsWNT2Bexpressionoftumortissuewasdifferentfromnormaltissue.WNT2Bwascorrelatedwithprognosis,cancer-associatedfibroblastinfiltration,immunoinfiltratingcells,tumorneoantigen,TMB,andMSI.ConclusionWNT2Bmayserveasabiomarkeroftumorimmunoinfiltrationandprognosis,providinganoveltargetforcancertreatment.Keywords:WNT2B;cancer;immunoinfiltration;biomarke...
