第46卷第1期2023年2月电子器件ChineseJournalofElectronDevicesVol.46No.1Feb．2023收稿日期:2022－01－06修改日期:2022－02－14NoninvasiveDetectionofHemoglobinBasedonPhotoplethysmographyXIAOYang1，ZHAOXingqun1*，YUZhengtao2(1．SchoolofBiologicalScienceandMedicalEngineering，SoutheastUniversity，NanjingJiangsu210096，China;2．NanjingOsteotechBiotechnologyCo．，Ltd．，NanjingJiangsu210046，China)Abstract:Todeterminethetotalhemoglobin(tHb)concentrationnoninvasively，ameasurementbasedonmulti-wavelengthphotoplethys-mography(PPG)isproposed．ThetheoreticalrelationshipbetweentHbcontentandPPGsignalsisderivedaccordingtomodifiedLambert-Beer’sLaw．ThenanoninvasivemeasurementsystemisconductedtocollectPPGsignalsfromfingertipirradiatedby6kindsofspecificwavelengthlightsources．Finally，theamplitudefeaturesofthesesignalsareextracted，andPartialLeastSquaresＲegression(PLSＲ)andSupportVectorＲegression(SVＲ)algorithmsareimplementedtopredicttHbconcentration．Experimentalresultsmanifestthatthepredictedvaluesofbothregressionmodelsarehighlycorrelatedwiththestandardvalues(r＞0．7)．SVＲachievesbetterperformance，themeanabsoluteerrorbetweenpredictedvaluesandstandardvaluesonall82samplesis0．8498g/dl，andthecorrelationcoefficientis0．8457．ThisstudyfurtherconfirmedthefeasibilityofnoninvasivedetectionoftHbconcentrationandprovidedaclinicallypracticalprototype．Keywords:totalhemoglobinconcentration;photoplethysmography;noninvasivemeasurement;regressionanalysisEEACC:7510Jdoi:10．3969/j．issn．1005－9490．2023．01．011基于光电容积脉搏波的血红蛋白无创检测技术肖杨1，赵兴群1*，俞政涛2(1．东南大学生物科学与医学工程学院，江苏南京210096;2．南京澳思泰生物科技有限公司，江苏南京210046)摘要:提出一种基于多波长光电容积脉搏波(PPG)的检测技术，实现人体总血红蛋白(tHb)浓度的无创测量。首先，根据改进的Lambert-Beer定律，推导tHb浓度与PPG信号的理论关系。然后，设计无创检测系统，采集6种特定波长光源照射下的PPG信号。最后，提取信号的幅度特征，分别应用偏最小二乘回归(PLSＲ)和支持向量回归(SVＲ)算法预测tHb浓度。实验结果表明，两种...
