广东化工2023年第6期·50·www.gdchem.com第50卷总第488期参术健脾和胃颗粒的制备工艺研究徐晓琰，汪永忠*，程耀堂，许高文，袁平凡(安徽省中西医结合医院药学部，安徽合肥230031)[摘要]目的：优选院内制剂参术健脾和胃颗粒的提取工艺和成型工艺。方法：采用正交试验法以加水量、煎煮时间和煎煮次数为考察因素，以陈皮中的主要有效成分橙皮苷的提取量为考察指标，优化最佳提取工艺；以溶化性和成型性为指标考察制剂最佳成型工艺。结果：优选出最佳制备工艺为原药材加10倍量水煎煮两次每次1.5小时，最佳成型工艺为糊精为辅料且用量为与干膏比例为0.8∶1。结论：确定了参术健脾和胃颗粒最佳提取和成型工艺，为院内制剂制备提供依据。[关键词]参术健脾和胃颗粒；提取工艺；成型工艺；制备工艺[中图分类号]TQ[文献标识码]A[文章编号]1007-1865(2023)06-0050-03StudyonPreparationTechnologyofShenzhuJianpiHeweiKeliXuXiaoyan,WangYongzhong*,ChengYaotang,XuGaowen,YuanPingfan(DepartmentofPharmacy,AnhuiprovinceHospitalonIntegrationofChineseandWesternMedicineDepartmentofPharmacy,Hefei230031,China)Abstract:Objective:TooptimizetheextractionandmoldingprocessofShenzhuJianpiheweiKeli.Methods:orthogonalexperimentaldesignwasusedtooptimizetheoptimalextractionprocess,takingthewateraddition,decoctingtimeanddecoctingtimesastheinvestigationfactors,theextractionamountofhesperidin,themaineffectivecomponentintangerinepeel,astheinvestigationindex,andthemoldingprocessofthepreparationwasinvestigatedwiththesolubilityandformabilityastheindexes.Results:theoptimumpreparationprocesswasthattheoriginalmedicinalmaterialwasdecoctedtwicewith10timestheamountofwater,eachtimefor1.5hours,dextrinwasusedasauxiliarymaterial,andtheratioofdextrintodryointmentwas0.8∶1.Conclusion:theoptimumpreparationtechnologyofShenzhuJianpiHeweiKeliwasdeterminedtoprovidebasisforthepreparationofhospitalpreparations.Keywords:ShenzhuJianpiheweiKeli；extractiontechnology；moldingtechnology；moldingandpreparationtechnology现今社会慢性胃炎的发病率急剧增加，严重影响着患者的生活质量。而慢性胃炎在中医学归属于“胃脘痛”“胃痞”“反酸”等病症范畴，临床上常见上腹部疼痛、恶心、烧灼感、反酸嗳气、饱腹感等...
