DOI:10.3969/j.issn.1672-7770.2023.02.016·临床研究·垂体腺瘤出血性卒中的危险因素分析李卓群,王宇翔,杨宇浩,尹宏伟,崔振文,丰育功,李照建【摘要】目的探讨影响垂体腺瘤出血性卒中发生的危险因素。方法回顾性分析青岛大学附属医院神经外科2010年1月—2021年1月收治的875例无功能垂体腺瘤患者的临床资料,并按照有无垂体腺瘤出血性卒中发生分为卒中组(88例)与非卒中组(787例),采用单因素分析及多因素Logistic回归分析筛选影响垂体腺瘤出血性卒中发生的危险因素。结果卒中组患者中,抗栓药物治疗史、肿瘤复发或残留、有介入手术或介入造影史的比例均明显高于非卒中组,微腺瘤的比例明显低于非卒中组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析提示,大腺瘤(OR=0.189,95%CI:0.069~0.522,P=0.001)、抗栓药物治疗史(OR=4.168,95%CI:1.611~10.785,P=0.003)、溴隐亭治疗(OR=2.912,95%CI:1.156~7.34,P=0.023)、肿瘤复发或残留(OR=2.787,95%CI:1.179~6.59,P=0.020)是垂体腺瘤出血性卒中的独立危险因素。结论存在大腺瘤、抗栓药物治疗史、溴隐亭治疗、肿瘤复发或残留等情况的垂体腺瘤患者较易发生垂体腺瘤出血性卒中。【关键词】垂体腺瘤;垂体腺瘤出血性卒中;溴隐亭;危险因素【中图分类号】R739.41【文献标志码】B【文章编号】1672-7770(2023)02-0203-05AnalysisofriskfactorsrelatedtohemorrhagicpituitaryapoplexyLIZhuo-qun,WANGYu-xiang,YANGYu-hao,etal.DepartmentofMedicine,QingdaoUniversity,Qingdao266000,ChinaCorrespondingauthor:LIZhao-jianAbstract:ObjectiveToinvestigatetheriskfactorsofhemorrhagicpituitaryadenomaapoplexy.MethodsTheclinicaldateof875patientswithnon-functioningpituitaryadenomafromJanuary2010toJanuary2021intheDepartmentofNeurosurgery,AffiliatedHospitalofQingdaoUniversitywereanalyzedretrospectively.Accordingtotheoccurrenceofpituitaryadenomahemorrhagicstroke,thepatientsweredividedintostrokegroup(88cases)andnon-strokegroup(787cases).Theriskfactorsaffectingtheoccurrenceofpituitaryadenomahemorrhagicstrokewerescreenedbyunivariateanalysisandmultivariatelogisticregressionanalysis.ResultsTheproportionofbromocriptinetherapy,thehistoryoftakingantithromboticdrugs,recurrentorresidualtumor,andthehistor...