Science 2018-01-12.pdf

CREDITS:(LEFT TO RIGHT)UNIVERSAL PICTURES/SCREENPROD/PHOTONONSTOP/ALAMY STOCK PHOTONASA;H.FORD(JHU);AUTZEN ET AL.12 JANUARY 2018 VOL 359 ISSUE 6372 13112 JANUARY 2018 VOLUME 359 ISSUE 6372CONTENTS160,228,&237How a channel senses calciumON THE COVERThe cover illustration reimagines the monster first conjured in Mary Shelleys 1818 novel.Two centuries later,the story of how the fictional Dr.Frankenstein built a creature from scavenged body parts and unleashed it on the world has lost none of its power to unsettle,and Frankenstein has become a byword for scientific overreach.See pages 137 and 146.Illustration:Craig&KarlINTRODUCTION146 After 200 years,Frankenstein is still essential reading for scientists By K.KupferschmidtFEATURES 148 HOW A HORROR STORYHAUNTS SCIENCEThe novel offers grist for psychologists and science historians,ammunition for technophobes,and even inspiration for researchers By J.Cohen151 CREATING A MODERN MONSTERA toolbox for Frankensteins of the 21st century By D.Shultz and A.Arranz152 TAMING THE MONSTERS OF TOMORROWA small group of researchers is studying how science could destroythe worldand how to stop that from happening By K.Kupferschmidt154 A GLOSSARY OF FRANKENWORDSMary Shelleys story provided the perfect prefix to nickname any unusual creation By J.Cohen EDITORIAL P.137;BOOKS ET AL.P.168;LETTERS P.170;VIDEOINSIGHTSPERSPECTIVES 156 DETECTING THE BUILDING BLOCKS OF AROMATICSDetection of benzonitrile in an interstellar cloud helps to constrain interstellar chemistry By C.Joblin and J.Cernicharo REPORT P.202157 IMPROBABLE BIG BIRDSDarwins finches prove a mechanism for the rapid formation of new species By C.E.Wagner REPORT P.224159 MALARIA PARASITE EVOLUTION IN A TEST TUBEExperimental evolution studies reveal drug targets and resistance mechanisms By J.M.Carlton RESEARCH ARTICLE P.191160 TRPM CHANNELS COME INTO FOCUSThe structures of TRPM channels help to explain how they can sense intracellular calcium By C.Bae et al.REPORTS PP.228&237162 COHERENT EXCITATIONS REVEALED AND CALCULATEDNeutron scattering and theoretical studies reveal wavelike electron states in CePd3 By A.Georges RESEARCH ARTICLE P.186SCIENCE sciencemag.org156NEWSIN BRIEF138 News at a glanceIN DEPTH 141 DOE PUSHES FOR USEFUL QUANTUM COMPUTINGAs quantum supremacy nears,so does a desire to apply machines to science problems By A.Cho PODCAST142 IN PAKISTAN,SURVEILLANCE FOR POLIO REVEALS A PARADOXCases are the lowest ever,but the virus persists in sewage By L.Roberts143 EARTH SCIENTISTS LIST TOP PRIORITIES FOR SPACE MISSIONSReport urges NASA to choose medium-size Earth-observing satellites through competition to keep costs down By P.Voosen144 CUBAS 100-YEAR PLAN FOR CLIMATE CHANGENation seeks assistance for project to strengthen coastal defenses and relocate villages By R.Stone145 CLIFFS OF ICE SPIED ON MARSBuried glaciers could be prime target for human exploration By P.Voosen REPORT P.199DA_0112TOC.indd 1311/10/18 10:39 AMPublished by AAASon January 14,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(TOP TO BOTTOM)YOSSI YOVEL;SHEN ET AL.12 JANUARY 2018 VOL 359 ISSUE 6372 133SCIENCE sciencemag.orgCONTENTS206Pores large and small12 JANUARY 2018 VOLUME 359 ISSUE 6372177 IMMUNOLOGYThe epigenetic control of stemness in CD8+T cell fate commitment L.Pace et al.PERSPECTIVE P.163186 SOLID-STATE PHYSICSCoherent band excitations in CePd3:A comparison of neutron scattering and ab initio theory E.A.Goremychkin et al.PERSPECTIVE P.162191 MALARIAL GENOMICSMapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics A.N.Cowell et al.PERSPECTIVE P.159REPORTS 199 MARTIAN GEOLOGYExposed subsurface ice sheets in the Martian mid-latitudes C.M.Dundas et al.202 ASTROCHEMISTRYDetection of the aromatic molecule benzonitrile(c-C6H5CN)in the interstellar medium B.A.McGuire et al.PERSPECTIVE P.156206 POROUS MATERIALSOrdered macro-microporous metal-organic framework single crystals K.Shen et al.210 INFECTIONAntagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence W.Zhao et al.NEUROSCIENCE213 Spatial representations of self and other in the hippocampus T.Danjo et al.218 Social place-cells in the bat hippocampus D.B.Omer et al.224 HYBRID SPECIATIONRapid hybrid speciation in Darwins finches S.Lamichhaney et al.PERSPECTIVE P.157228 STRUCTURAL BIOLOGYStructure of the human TRPM4 ion channel in a lipid nanodisc H.E.Autzen et al.PERSPECTIVE P.160;REPORT P.237232 GUT IMMUNITYCX3CR1+mononuclear phagocytes control immunity to intestinal fungi I.Leonardi et al.237 STRUCTURAL BIOLOGYStructure of the cold-and menthol-sensing ion channel TRPM8 Y.Yin et al.PERSPECTIVE P.160;REPORT P.228SCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2018 by the American A