Science 2018-04-20.pdf

sr27hsjzmsplCREDITS(TOP TO BOTTOM):(IMAGE)V.ALTOUNIAN/SCIENCE;(PHOTO)ISTOCK.COM/OZTURK20 APRIL 2018 VOL 360 ISSUE 6386 239SCIENCE sciencemag.org20 APRIL 2018 VOLUME 360 ISSUE 6386CONTENTS254A molecular suspectin kidney failure265 WHISPERING NEURONS FUEL CORTICAL HIGHWAYSSynaptic communication accelerates neuronal migration in the developing brain By A.F.Schinder and G.M.Lanuza REPORT P.313267 PARKIN FUNCTION IN PARKINSONS DISEASEModels of Parkin-mediated ubiquitination lend insight into the role of pathological mutations By C.Arkinson and H.Walden269 IF TWO DELETIONS DONT STOP GROWTH,TRY THREETriple mutations in yeast reveal broad scope of genetic interactions By A.J.M.Walhout RESEARCH ARTICLE P.283270 A UNIFYING CONCEPT INVASCULAR HEALTH AND DISEASEInterventions to restore blood vessel stability could improve health outcomes By M.A.Schwartz et al.BOOKS ET AL.272 RECONSIDERING THE NOBEL PRIZEAfter dust stymies a quest to confirm cosmic inflation,a physicist questions sciences most prestigious award By P.Halpern274 WIELDING NEW GENOMICTOOLS WISELYTroubling traces of biocolonialism undermine an otherwise eloquent synthesis of ancient genome research By M.C.vila ArcosLETTERS 276 IVORY CRISIS:GROWINGNO-TRADE CONSENSUSBy N.Sekar et al.277 IVORY CRISIS:ROLE OFBIOPRINTING TECHNOLOGYBy M.Lenda et al.277 RESPONSEBy D.Biggs et al.278 INSURANCE COVERAGE FOR GENOMIC TESTSBy K.A.Phillips et al.253 PROPOSAL TO RESCUE POSTDOCS FROM LIMBO DRAWS DARTSExpert panel offers mix of old and new ideas to help young biomedical researchers build stable careers By M.PriceFEATURE 254 OMEN IN THE BLOODA protein marker predicts health crisesbut can it cause them?By S.HallINSIGHTSPOLICY FORUM 260 RISK-BASED REBOOT FOR GLOBAL LAB BIOSAFETYNew WHO guidance could expand access to lab facilities By K.Kojima et al.PERSPECTIVES 263 PLANT RESPONSES TO CO2 ARE A QUESTION OF TIMELong-term experiments show unexpected plant responses to elevated CO2 concentrations By M.Hovenden and P.Newton REPORT P.317264 ON THE QUEST FORTHE STRONGEST MATERIALSDiamond nanoneedles have strength approaching the theoretical maximum By J.LLorca REPORT P.300249NEWSIN BRIEF244 News at a glanceIN DEPTH 247 NASA LANDER TO PROBE INTERIOR OF MARSBy listening for marsquakes,InSight will measure Red Planets core,mantle and crust By P.Voosen248 DEPARTMENT OF STATES AIR POLLUTION SENSORS GO GLOBALFine-particle sentinels prod governments to curb emissions By E.Kintisch249 CANNABIS,OPIUM USE PART OF ANCIENT NEAR EASTERN CULTURESGrowing body of data suggests ritual drug use by ancient Mesopotamians,Cypriots,and others By A.Lawler250 PLAN FOR 2020 U.S.CENSUS IS FATALLY FLAWED,CRITICS SAYUsing existing records to ensure accuracy is unlikely to succeed,experts predict By J.Mervis252 ANCIENT DNA UNTANGLES SOUTH ASIAN ROOTSStudy shores up steppe as long-sought Proto-Indo-European homeland By L.WadeDA_0420TOC.indd 2394/18/18 9:26 AMPublished by AAASon April 22,2018 http:/science.sciencemag.org/Downloaded from CREDITS(TOP TO BOTTOM):KUZMIN ET AL.;WANG ET AL.20 APRIL 2018 VOL 360 ISSUE 6386 241SCIENCE sciencemag.orgCONTENTS269&283 A landscape of genetic interactions20 APRIL 2018 VOLUME 360 ISSUE 6386RESEARCHIN BRIEF 280 From Science and other journalsRESEARCH ARTICLES 283 YEAST GENOMICSSystematic analysis of complex genetic interactions E.Kuzmin et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aao1729 PERSPECTIVE P.269284 ADVANCED IMAGINGObserving the cell in its native state:Imaging subcellular dynamics in multicellular organisms T.-L.Liu et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaq1392285 QUANTUM OPTICSMultidimensional quantum entanglement with large-scale integrated optics J.Wang et al.REPORTS 291 NANOPHOTONICSProbing the ultimate plasmon confinement limits with a van der Waals heterostructure D.Alcaraz Iranzo et al.296 MATERIALS SCIENCECapillarity-induced folds fuel extreme shape changes in thin wicked membranes P.Grandgeorge et al.300 MATERIALS SCIENCEUltralarge elastic deformation of nanoscale diamond A.Banerjee et al.PERSPECTIVE P.264303 COLLOIDSFive-dimensional imaging of freezing emulsions with solute effects D.Dedovets et al.307 QUANTUM GASESRecurrences in an isolated quantum many-body system B.Rauer et al.310 EXTINCTIONBody size downgrading of mammals over the late Quaternary F.A.Smith et al.313 NEURODEVELOPMENTSynaptic transmission from subplate neurons controls radial migration of neocortical neurons C.Ohtaka-Maruyama et al.PERSPECTIVE P.265317 PLANT ECOLOGYUnexpected reversal of C3 versus C4 grass response to elevated CO2 during a 20-year field experiment P.B.Reich et al.PERSPECTIVE P.263;PODCAST320 EARLY EARTHTwo-billion-year-old evaporites capture Earths great oxidation C.L.Blttler et al.323 STRUCTURAL BIOLOGYStructure of a prehandover mammalian ribosomal SRPSRP receptor targeting complex K.Kobayashi et al.327 AUTISM GENOMICSPaternally inherited cis-regulatory structural variants are associated with autism W.M.Brandler