PHOTO(BOTTOM):NOAHBERGER25NOVEMBER2016•VOL354ISSUE6315941SCIENCEsciencemag.org25NOVEMBER2016•VOLUME354•ISSUE6315CONTENTS958Anancientmigrant’stoolkitNEWSINBRIEF948NewsataglanceINDEPTH951REPUBLICANSREADYAREGULATORYROLLBACKSeldom-usedlawwillgiveTrump,CongressfreereintocancelscoresofrecentrulesByD.MalakoffINSIGHTSLETTERS964RESEARCHNIGHTOWLS▶CIRCADIANPHYSIOLOGYSECTIONP.986PERSPECTIVES967PROINFLAMMATORYPRIMATESSocialsubordinationinducesproinflammatorygeneexpressionprofilesByR.M.Sapolsky▶REPORTP.1041968CLOSINGTHELOOPTheATGconjugationsystemisnotessentialforautophagosomeformationinmammalsByB.Levine▶REPORTP.1036970TEACHINGNATURETHEUNNATURALAreengineeredenzymecatalyzesC−SibondformationByH.F.T.KlareandM.Oestreich▶REPORTP.1048971MOSQUITOESONTHEMOVESpreadandhybridizationofAedesaegyptimosquitoesraisetheriskofZika,dengue,andotherviralepidemicsByJ.R.Powell95AnmigONTHECOVERAnight-shiftworkerontheVictorialineoftheLondonUndergroundrailwayisoneofmanypeoplewhosejoborlifestylechoicesdissociatethemfromthenormallight-darkcyclesoftheenvironment.Thephysiologicalconsequencesofsuchcircadianmisalignmentaredescribedinaspecialsectionbeginningonpage986.Photo:PeterMacdiarmid/GettyImagesSEEALSO▶LETTERSP.964▶PODCAST▶VIDEOINTRODUCTION986OntheclockNEWS988ThescientificnightshiftByS.KeanPERSPECTIVE992Circadianclocks:Notyourgrandfather’sclockF.W.TurekREVIEWS994CircadiantimesignaturesoffitnessanddiseaseJ.BassandM.A.Lazar999ImmunityaroundtheclockK.Manetal.1004Mechanismslinkingcircadianclocks,sleep,andneurodegenerationE.S.MusiekandD.M.Holtzman1008CircadianphysiologyofmetabolismS.PandaSPECIALSECTIONCIRCADIANPHYSIOLOGY952GASCHANGESSIGNALERUPTIONSShiftinggasmixwarnsthatmagmaisontheriseByJ.Rosen953CATCHINGANCIENTMAIZEDOMESTICATIONINTHEACT5000-year-oldMexicancobsofferadetailedgeneticsnapshotofthepartlydomesticatedgrainByJ.Boddy954GRAVEYARDOFCOLDSLABSMAPPEDINEARTH’SMANTLEResurrectedtectonicplatesyieldvisionsofalostplanetByP.Voosen956ROGUEPROTEIN’SPARTNERSOFFERHOPEINPARKINSON’SDISEASETworeceptormo...
