Science 2016-11-25.pdf

PHOTO(BOTTOM):NOAH BERGER25 NOVEMBER 2016 VOL 354 ISSUE 6315 941SCIENCE sciencemag.org25 NOVEMBER 2016 VOLUME 354 ISSUE 6315CONTENTS958An ancient migrants toolkitNEWSIN BRIEF948 News at a glanceIN DEPTH 951 REPUBLICANS READY A REGULATORY ROLLBACKSeldom-used law will give Trump,Congress free rein to cancel scores of recent rules By D.MalakoffINSIGHTSLETTERS 964 RESEARCH NIGHT OWLS CIRCADIAN PHYSIOLOGY SECTION P.986PERSPECTIVES 967 PROINFLAMMATORY PRIMATESSocial subordination induces proinflammatory gene expression profiles By R.M.Sapolsky REPORT P.1041968 CLOSING THE LOOPThe ATG conjugation system is not essential for autophagosome formation in mammals By B.Levine REPORT P.1036970 TEACHING NATURE THE UNNATURALA reengineered enzyme catalyzes CSi bond formation By H.F.T.Klare and M.Oestreich REPORT P.1048971 MOSQUITOES ON THE MOVESpread and hybridization of Aedes aegypti mosquitoes raise the risk of Zika,dengue,and other viral epidemics By J.R.Powell95An migON THE COVERA night-shift worker on the Victoria line of the London Underground railway is one of many people whose job or lifestyle choices dissociate them from the normal light-dark cycles of the environment.The physiological consequences of such circadian misalignment are described in a special section beginning on page 986.Photo:Peter Macdiarmid/Getty ImagesSEE ALSO LETTERS P.964 PODCAST VIDEOINTRODUCTION 986 On the clockNEWS988 The scientific night shift By S.KeanPERSPECTIVE992 Circadian clocks:Not your grandfathers clock F.W.TurekREVIEWS994 Circadian time signatures of fitness and disease J.Bass and M.A.Lazar999 Immunity around the clock K.Man et al.1004 Mechanisms linking circadian clocks,sleep,and neurodegeneration E.S.Musiek and D.M.Holtzman1008 Circadian physiology of metabolism S.PandaSPECIAL SECTIONCIRCADIAN PHYSIOLOGY952 GAS CHANGES SIGNAL ERUPTIONSShifting gas mix warns that magma is on the rise By J.Rosen953 CATCHING ANCIENT MAIZE DOMESTICATION IN THE ACT5000-year-old Mexican cobs offer a detailed genetic snapshot of the partly domesticated grain By J.Boddy954 GRAVEYARD OF COLD SLABS MAPPED IN EARTHS MANTLEResurrected tectonic plates yield visions of a lost planet By P.Voosen956 ROGUE PROTEINS PARTNERS OFFER HOPE IN PARKINSONS DISEASETwo receptor molecules may offer targets for drugs By M.WadmanFEATURE 958 THE WANDERERS Fossils of the first human ancestors to trek out of Africa reveal primitive features and a brutal way of life By A.Gibbons956Published by AAAS on November 24,2016http:/science.sciencemag.org/Downloaded from 25 NOVEMBER 2016 VOL 354 ISSUE 6315 943SCIENCE sciencemag.orgCONTENTS970&1048Organosilicon comes to life 25 NOVEMBER 2016 VOLUME 354 ISSUE 6315RESEARCHIN BRIEF 1016 From Science and other journalsRESEARCH ARTICLES 1019 HUMAN DEVELOPMENTAn interactive three-dimensional digital atlas and quantitative database of human development B.S.de Bakker et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aag00531020 CELL REPROGRAMMINGTissue damage and senescence provide critical signals for cellular reprogramming in vivo L.Mosteiro et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf4445REPORTS COLD ATOMS 1021 An atom-by-atom assembler of defect-free arbitrary two-dimensional atomic arrays D.Barredo et al.1024 Atom-by-atom assembly of defect-free one-dimensional cold atom arrays M.Endres et al.PERSPECTIVE P.9721027 GEOPHYSICSMega-earthquakes rupture flat megathrusts Q.Bletery et al.1031 CATALYSISDirect and continuous strain control of catalysts with tunable battery electrode materials H.Wang et al.1036 AUTOPHAGYThe ATG conjugation systems are important for degradation of the inner autophagosomal membrane K.Tsuboyama et al.PERSPECTIVE P.9681041 BEHAVIORAL IMMUNOLOGYSocial status alters immune regulation and response to infection in macaques N.Snyder-Mackler et al.PERSPECTIVE P.9671046 MEMORY RESEARCHRetrieval practice protects memory against acute stress A.M.Smith et al.1048 BIOCATALYSISDirected evolution of cytochrome c for carbonsilicon bond formation:Bringing silicon to life S.B.J.Kan et al.PERSPECTIVE P.970SCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2016 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership and subscription(51 issues):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1522;Foreign postage extra:Mexico,Caribbean(surface mail)$55;other countries(air assist delivery)$89.First class,airmail,student,and emeritus rates on request.Canadian rates with GST available upon request,GST#1254 88122.Publications Mail Agreement Number 1069624.Printed in the U.S.A.Change of address:Allow 4 weeks,giving old and new add