Science 2018-02-02.pdf

CREDITS:(LEFT TO RIGHT)(PHOTO)DUNEDIN MULTIDISCIPLINARY HEALTH AND DEVELOPMENT RESEARCH UNIT,UNIVERSITY OF OTAGO;(GRAPHIC)K.SUTLIFF/SCIENCE2 FEBRUARY 2018 VOL 359 ISSUE 6375 493SCIENCE sciencemag.org2 FEBRUARY 2018 VOLUME 359 ISSUE 6375CONTENTS516&582Predicting immunotherapy response 516 ENHANCING RESPONSES TO CANCER IMMUNOTHERAPYThe capacity of antigen presentation influences responses to checkpoint immunotherapy By P.Kvistborg and J.W.Yewdell REPORT P.582517 STEALTH REACTIONS DRIVINGCARBON FIXATIONNew twists to bacterial metabolic pathways that contribute to the global carbon cycle By S.W.Ragsdale REPORTS PP.559&563519 LIGHTING UP SUPERCONDUCTING STRIPESTerahertz radiation reveals pair density waves in underdoped cuprate superconductors By E.Ergeen and N.Gedik REPORT P.575520 GALAXY MOTIONS CAUSE TROUBLE FOR COSMOLOGYSatellite galaxy motions around a nearby galaxy seem to be at odds with dark matter models By M.Boylan-Kolchin RESEARCH ARTICLE P.534521 TRACING SINGLE-CELL HISTORIESOrigins of mutations in single cells during human brain development and aging are revealed By J.H.Lee RESEARCH ARTICLE P.550;REPORT P.555 POLICY FORUM 523 SCIENTIFICALLY ASSESS IMPACTSOF SUSTAINABLE INVESTMENTSMetrics can inform investors wary of“green washing”By C.J.Vrsmarty et al.BOOKS ET AL.526 PICTURING THE FUTUREA new film celebrates a mid-century illustrator who stoked imaginations with prescient comics By D.Greenbaum527 THE FETISHIZATION OFQUANTIFICATIONA historian explores the dark side of metric-based performance evaluation By T.M.Porter507 ACCELERATOR BOOM HONES CHINAS ENGINEERING EXPERTISEBevy of particle accelerators could pave the way for future collider that would be worlds largest By D.Normile508 DAMS NUDGE AMAZONS ECOSYSTEMS OFF-KILTERDecline of giant catfish emblematic of habitat fragmentation By B.Fraser SCIENCE ADVANCES RESEARCH ARTICLE BY E.P.ANDERSON ET AL.10.1126/sciadv.aao1642FEATURE 510 HUMAN NATURE,OBSERVEDFor decades,two psychologists have kept watch over 1000 New Zealanders,teasing out factors that shape a lifes course By D.Starr PODCAST510INSIGHTSPERSPECTIVES 514 OUT OF BALANCE IN THE ARCTICPolar bears have high energy requirements that rise further as a result of climate change By J.P.Whiteman REPORT P.568NEWSIN BRIEF500 News at a glanceIN DEPTH 503 INDIA PLANS TO LAND NEAR MOONS SOUTH POLEChandrayaan-2 orbiter could slake scientists thirst for detailed data on lunar water By P.Bagla504 JUDGE ORDERS UNMASKING OF ANONYMOUS PEER REVIEWERSBitter legal battle between two physical fitness groups produces unusual court decision By A.Han 505 NASA SEEKS TO REVIVE LOST PROBE THAT TRACED SOLAR STORMSAmateur found IMAGE while looking for spy satellite By P.Voosen506 FOREVER YOUNG?NAKED MOLE RATS MAY KNOW THE SECRETA new study claims the strange rodents flout the mathematics of mortalitybut not everyone is convinced By K.KupferschmidtGranting complete confidentiality,landmark study has followed New Zealanders from birth.DA_0202TOC.indd 4931/31/18 10:48 AMPublished by AAASon February 3,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(TOP TO BOTTOM)(GRAPHIC)H.ZHU ET AL.;(PHOTO)BRIAN BATTAILE,USGS2 FEBRUARY 2018 VOL 359 ISSUE 6375 495SCIENCE sciencemag.orgCONTENTS579Phonons left and right2 FEBRUARY 2018 VOLUME 359 ISSUE 6375REPORTS 555 NEURODEVELOPMENTAging and neurodegeneration are associated with increased mutations in single human neurons M.A.Lodato et al.PERSPECTIVE P.521;RESEARCH ARTICLE P.550CARBON FIXATION559 A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile T.Nunoura et al.563 Reversibility of citrate synthase allows autotrophic growth of a thermophilic bacterium A.Mall et al.PERSPECTIVE P.517568 ECOPHYSIOLOGYHigh-energy,high-fat lifestyle challenges an Arctic apex predator,the polar bear A.M.Pagano et al.PERSPECTIVE P.514;VIDEO572 SURFACE SCIENCEPolarity compensation mechanisms on the perovskite surface KTaO3(001)M.Setvin et al.575 SUPERCONDUCTIVITYProbing optically silent superfluid stripes in cuprates S.Rajasekaran et al.PERSPECTIVE P.519579 TOPOLOGICAL MATTERObservation of chiral phonons H.Zhu et al.582 CANCER IMMUNOTHERAPYPatient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy D.Chowell et al.PERSPECTIVE P.516587 MOLECULAR BIOLOGYThe piRNA targeting rules and the resistance to piRNA silencing in endogenous genes D.Zhang et al.592 COLON CANCERPatients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria C.M.Dejea et al.ON THE COVERMultiwavelength composite image of the elliptical galaxy Centaurus A,revealing a prominent dust lane and jets emanating from its central supermassive black hole.Dwarf satellite galaxies that orbit Centaurus A beyond the field of view are found to rotate in a coherent plane,perpendicular to the dust lane.That rotating plane of satellite galaxies challenges the standard cosmological paradigm.See pages 520 and 534.Image:ESO/WFI(optical data);MPIfR/ESO/APEX