Science 2018-11-16.pdf

CREDITS:(TOP)R.FREEMAN ET AL.;(BOTTOM)PHOTO:SCOTT SUCHMAN;STYLING:NICHOLE BRYANT16 NOVEMBER 2018 VOL 362 ISSUE 6416 721SCIENCE sciencemag.org16 NOVEMBER 2018 VOLUME 362 ISSUE 6416CONTENTS808Superstructured biocompatible gelsINSIGHTSPERSPECTIVES 744 LIGHTING UP THE NIGHTTIMEArtificial light at night needs to be reduced to limit negative environmental impacts By K.J.Gaston746 ENDOTHELIAL CELL TRANSITIONSAre endothelial-to-mesenchymal transitions in various vascular pathologies a consequence,cause,or defense?By E.Dejana and M.G.Lampugnani748 A TARGET TO SUPPRESS INFLAMMATIONA small-molecule inhibitor of the OGG1 DNA glycosylase has anti-inflammatory effects By L.D.Samson REPORT P.834749 CELL TYPES BEHAVING IN THEIR NATURAL HABITATDefining cell types in situ connects gene expression,anatomy,and function during certain behaviors By B.Tasic and P.R.Nicovich RESEARCH ARTICLE P.792750 POLARIMETRY ENABLED BY NANOPHOTONICSNanoantenna and plasmonic structures can be used to measure light polarization By A.Martnez752 PAUL G.ALLEN(19532018)Cofounder of Microsoft,visionary,and philanthropist By R.Horwitz et al.POLICY FORUM 753 PREVENTING CHEMICAL WEAPONS AS SCIENCES CONVERGEFocus must extend beyond 20th-century technologies By M.Crowley et al.BOOKS ET AL.756 APPROACHING THE SINGULARITYNew data,old rivalries,and enduring questions fill a welcome overview of black hole research By J.SchnittmanON THE COVERThe millennials may be onto something.Their favored avocado toast features a mixture of healthy fats,seeds,and grains recommended by nutrition experts in a consensus reading of available scientific studies.This special issue explores what we knowand what we need to learnabout defining a healthy diet that can sustain a strong body and protect against age-associated diseases.See page 762.Photo:Scott Suchman;Styling:Nichole BryantSPECIAL SECTIONDIET AND HEALTHINTRODUCTION 762 Optimizing the dietREVIEWS764 Dietary fat:From foe to friend?D.S.Ludwig et al.770 A time to fast A.Di Francesco et al.PODCAST776 The gut microbiota at the intersection of diet and human health C.L.Gentile and T.L.Weir781 Swifter,higher,stronger:Whats on the menu?L.M.Burke and J.A.HawleyNEWSIN BRIEF728 News at a glanceIN DEPTH 731 VOTE HERALDS FRESH START FOR SCIENCE PANELDemocratic win of House of Representatives will bring new tone to research issues By J.Mervis PODCAST733 ERUPTION MADE 536 THE WORST YEAR TO BE ALIVECore from glacier reveals the Icelandic volcano that plunged Europe into darkness By A.Gibbons PODCAST734 OBESITY GIVES UNEXPECTED BOOST TO ANTICANCER DRUGSDrugs revive immune cells exhausted by obesity hormone By J.Kaiser735 FRESH FIGHTS ROIL EVIDENCE-BASED MEDICINE GROUPExpelled Cochrane co-founder Peter Gtzsche is suspended as head of the Nordic Cochrane CentreBy G.Vogel736 REPROGRAMMED CELLS COULD TACKLE BRAIN DAMAGETurning astrocytes into neurons improves symptoms in preliminary mouse studies By K.Servick737 LARGE GALAXY FOUND LURKING ON THE MILKY WAYS FAR SIDEAntlia 2 rivals the Large Magellanic Cloud in size but is strangely dim,a puzzle for theorists By A.MannFEATURE 738 ICE AGE IMPACTA large asteroid struck Greenland in the time of humans.How did it affect the planet?By P.Voosen VIDEO;SCI.ADV.RESEARCH ARTICLE BY K.H.KJR ET AL.10.1126/sciadv.aar8173CREDICREDITS:(TS:(TOP)TOP)R.FRR.FREEMANEEMAN ET ALET AL.;(B.;(BOTTOMOTTOM)PHO)PHOTO:SCOTT COTT SUCHMSUCHMAN;STYLIN NG:NICHOLCHOLE7T TTimm7OACdBy F F F7AttKPublished by AAASon November 19,2018 http:/science.sciencemag.org/Downloaded from 821 ULTRAFAST DYNAMICSBeyond the molecular movie:Dynamics of bands and bonds during a photoinduced phase transition C.W.Nicholson et al.825 NETWORK SCIENCEQuantifying reputation and success in art S.P.Fraiberger et al.829 MASS SPECTROMETRYProtein assemblies ejected directly from native membranes yield complexes for mass spectrometry D.S.Chorev et al.834 INFLAMMATIONSmall-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation T.Visnes et al.PERSPECTIVE P.748839 BIOTECHNOLOGYProgrammed DNA destruction by miniature CRISPR-Cas14 enzymes L.B.Harrington et al.804CREDITS:(CLOCKWISE FROM TOP)J.S.LEE ET AL.;K.C.K.CHENG ET AL.;ALL CANADA PHOTOS/ALAMY STOCK PHOTO16 NOVEMBER 2018 VOL 362 ISSUE 6416 723SCIENCE sciencemag.orgCONTENTS817Single-crystal hBN films16 NOVEMBER 2018 VOLUME 362 ISSUE 6416RESEARCHIN BRIEF 788 From Science and other journalsRESEARCH ARTICLES 791 CELL METABOLISMSFXN1 is a mitochondrial serine transporter required for one-carbon metabolism N.Kory et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat9528792 NEUROGENOMICSMolecular,spatial,and functional single-cell profiling of the hypothalamic preoptic region J.R.Moffitt et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aau5324 PERSPECTIVE P.749793 NEURODEVELOPMENTIn vivo modeling of human neuron dynamics and Down syndrome R.Real et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aau1810794 TROPICAL STORM