DOI:10．3969/j．issn．1672-7770．2023．02．012·论著·LncRNASLC26A4-AS1在人垂体瘤组织中的表达及其意义彭超，李晏丽，袁勇【摘要】目的探讨lncRNASLC26A4-AS1在人垂体瘤中的表达情况，并分析其与垂体瘤侵袭性的关系。方法收集经病理确诊的16例非侵袭性垂体瘤和25例侵袭性垂体瘤，利用实时荧光定量聚合酶链反应技术检测SLC26A4-AS1在人垂体瘤中的表达，并进一步分析SLC26A4-AS1与垂体瘤临床参数的相关性。结果与非侵袭性垂体瘤相比，SLC26A4-AS1在侵袭性垂体瘤中表达降低;与无功能瘤相比，SLC26A4-AS1在泌乳素瘤、生长激素瘤和促肾上腺皮质激素瘤中表达无明显差异。与SLC26A4-AS1高表达组相比，SLC26A4-AS1低表达组中肿瘤体积≥3cm3的比例明显增加、侵袭性垂体瘤的比例明显增加，差异具有统计学意义(P＜0．05)。结论SLC26A4-AS1在侵袭性垂体瘤中表达降低，SLC26A4-AS1的低表达与肿瘤体积和侵袭性相关。【关键词】垂体瘤;侵袭性;长链非编码RNA;SLC26A4-AS1【中图分类号】R739．41【文献标志码】A【文章编号】1672-7770(2023)02-0183-06ExpressionandsignificanceoflncRNASLC26A4-AS1inhumanpituitaryadenomaPENGChao，LIYan-li，YUANYong．DepartmentofNeurosurgery，GuangdongProvincialPeople'sHospital，Guangzhou510080，ChinaCorrespondingauthor:YUANYongAbstract:ObjectiveToinvestigatetheexpressionoflncRNASLC26A4-AS1inhumanpituitaryadenomaandanalyzeitsrelationshipwiththeinvasivenessofpituitaryadenoma．MethodsTheexpressionofSLC26A4-AS1wasmeasuredin41specimensofpituitaryadenomasincludinginvasivepituitaryadenomas(n=21)andnoninvasivepituitaryadenoma(n=16)byreal-timequantitativereversetranscriptionpolymerasechainreaction．Then，thecorrelationbetweenSLC26A4-AS1expressionandclinicalfeaturesofpatientswithpituitaryadenomaswereanalyzed．ResultsTheexpressionofSLC26A4-AS1wasdecreasedininvasivepituitaryadenomascomparedwithnoninvasivepituitaryadenomas．TherewasnodifferenceofSLC26A4-AS1expressionbetweenPRLadenoma，GHadenomaandACTHadenomaandnonfunctionaladenomas．ComparedwiththeSLC26A4-AS1high-expressiongroup，theproportionoftumorvolume≥3cm3andtheproportionofinvasivepituitaryadenomaintheSLC26A4-AS1low-expressiongroupweresignificantlyincreased(P＜0．05)．ConclusionsTh...
