Science 2018-11-02.pdf

CREDITS(FROM TOP):BABYAN ET AL.;HUMPHREY/SHUTTERSTOCK2 NOVEMBER 2018 VOL 362 ISSUE 6414 499SCIENCE sciencemag.org2 NOVEMBER 2018 VOLUME 362 ISSUE 6414CONTENTS524&577Predicting viral origins SPECIAL SECTIONCOMPOSITE MATERIALSINSIGHTSPERSPECTIVES 518 SHIFTING SUMMER RAINSTrace-element records in Chinese caves reveal the effects of climate change on Asian monsoons By D.McGee REPORT P.580520 IDENTIFYING POSTURE CELLS IN THE BRAINThe parietal cortex represents body posture and other factors in spatial awareness By G.Chen REPORT P.584521 CANCER ENZYME AFFECTS PARKINSONS DISEASENew insights identify a possible target for slowing neurodegeneration By P.Brundin and R.Wyse RESEARCH ARTICLE P.557523 EVOLVING A PATHOGEN TO BE PROTECTIVEThe deadly fungus Candida albicans can be pushed to protect its mammalian host By C.dEnfert REPORT P.589524 SOURCES OF HUMAN VIRUSESMachine learning predicts the hosts and vectors of RNA viruses that can infect humans By M.Woolhouse REPORT P.577ON THE COVERThis whimsical photo of a coconut turned into a car represents the increasing use of natural materials in commercial composites,particu-larly in the automotive sector.Coconut fibers(coir)and powdered coconut shells can be combined with a variety of polymers to make car parts,including door cladding,structural guards,and internal components.For more on the investigation and application of biological,hybrid,and carbon-based composite materials,see page 534.Photo:Cary and Babs WolinskyNEWSIN BRIEF504 News at a glanceIN DEPTH 507 SEAFLOOR MAPPERS TO COMPETE FOR XPRIZEFaster,cheaper autonomous systems could aid in resource extraction and science By J.Rosen508 ADVANCES IN FLOW BATTERIES PROMISE CHEAP BACKUP POWERUpstart technology could enable widespread adoption of renewables By R.F.Service510 MICROBIOME CONSERVANCY STORES GLOBAL FECAL SAMPLESResearch could help prevent or treat diseases of the gut By T.Rabesandratana511 LLAMA ANTIBODIES INSPIRE GENE SPRAY TO PREVENT ALL FLUSStrategy for mutable virus might outdo traditional vaccines By J.Cohen REPORT P.598512 EUROPES 1 BILLION QUANTUM FLAGSHIP ANNOUNCES GRANTSProgram aims to nudge quantum technology to market By E.Cartlidge513 SUSPECT SCIENCE LEADS TO PAUSE IN STEM CELL TRIALHarvard University finds fraud in 31 papers,casting doubt on study rationale By Jocelyn KaiserINTRODUCTION 534 Mixing and matching materialsREVIEWS536 Composites from renewable and sustainable resources:Challenges and innovations A.K.Mohanty et al.543 Biological compositescomplex structures for functional diversity M.Eder et al.PODCAST547 Composites with carbon nanotubes and graphene:An outlook I.A.Kinloch et al.FEATURES 514 MOMENTS TO SPARECalifornias new earthquake warning system delivers just seconds of notice.Even that is a victory By P.Voosen518&580DA_1102TOC.indd 49910/30/18 7:02 PMPublished by AAASon November 5,2018 http:/science.sciencemag.org/Downloaded from CREDITS(FROM TOP):KUJIRAI ET AL.;ROBERT NEUBECKER2 NOVEMBER 2018 VOL 362 ISSUE 6414 501SCIENCE sciencemag.orgCONTENTS595Snapshot of nucleosomal transcription 2 NOVEMBER 2018 VOLUME 362 ISSUE 6414RESEARCH ARTICLES 557 NEURODEGENERATIONPoly(ADP-ribose)drives pathologic a-synuclein neurodegeneration in Parkinsons disease T.-I.Kam et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat8407 PERSPECTIVE P.521558 DRUG DISCOVERYDefining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN Q.L.Sievers et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat0572559 METALLURGYExtra strengthening and work hardening in gradient nanotwinned metals Z.Cheng et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aau1925REPORTS 560 NANOMATERIALSA general synthesis approach for supported bimetallic nanoparticles via surface inorganometallic chemistry K.Ding et al.564 ORGANIC CHEMISTRYCatalytic palladium-oxyallyl cycloaddition B.M.Trost et al.568 QUANTUM OPTICSTopological protection of biphoton states A.Blanco-Redondo et al.572 PHYSICSUltrafast disordering of vanadium dimers in photoexcited VO2 S.Wall et al.PERSPECTIVE P.525577 EPIDEMIOLOGYPredicting reservoir hosts and arthropod vectors from evolutionary signatures in RNA virus genomes S.A.Babayan et al.PERSPECTIVE P.524580 PALEOCLIMATOLOGYEast Asian hydroclimate modulated by the position of the westerlies during Termination I H.Zhang et al.PERSPECTIVE P.518584 NEUROSCIENCEEfficient cortical coding of 3D posture in freely behaving rats B.Mimica et al.PERSPECTIVE P.520589 MICROBIOTAExperimental evolution of a fungal pathogen into a gut symbiont G.H.W.Tso et al.PERSPECTIVE P.523595 STRUCTURAL BIOLOGYStructural basis of the nucleosome transition during RNA polymerase II passage T.Kujirai et al.598 ANTI-FLU THERAPYUniversal protection against influenza infection by a multidomain antibody to influenza hemagglutinin N.S.Laursen et al.NEWS STORY P.5115 59SnatSCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the Amer