Science 2018-12-14.pdf

GRAPHIC:C.BICKEL/SCIENCE14 DECEMBER 2018 VOL 362 ISSUE 6420 1211SCIENCE sciencemag.org14 DECEMBER 2018 VOLUME 362 ISSUE 6420CONTENTSNEWSIN BRIEF1218 News at a glanceIN DEPTH 1222 IRELAND SLASHES PEAT POWER TO LOWER EMISSIONSHarvested from drained and denuded bogs,peat is more polluting than coal By E.Toner1223 TRUMP OFFICIALS MOVE TO LIMIT HUMAN FETAL TISSUE RESEARCHNIH ordered staff scientists not to procure new tissue By M.Wadman and J.Kaiser1224 U.N.HIV/AIDS AGENCY ASSAILED FOR CULTURE OF HARASSMENTIndependent panel calls for replacing executive director By J.Cohen1225 WORRIES ABOUT EBOLA OUTBREAK GROW,DESPITE USE OF VACCINEDRC conflict hampers effort to track and contain virus By J.Cohen1230Great scopes!Astronomers dream bigINTRODUCTION 1262 Revealing the brains molecular architecture The PsychENCODE ConsortiumRESEARCH ARTICLES1264 Integrative functional genomic analysis of human brain development and neuropsychiatric risks M.Li et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat76151265 Transcriptome-wide isoform-level dysregulation in ASD,schizophrenia,and bipolar disorder M.J.Gandal et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat81271266 Comprehensive functional genomic resource and integrative model for the human brain D.Wang et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat84641267 Spatiotemporal transcriptomic divergence across human and macaque brain development Y.Zhu et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat80771268 Transcriptome and epigenome landscape of human cortical development modeled in organoids A.Amiri et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat67201269 Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk P.Rajarajan et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat43111270 Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder J.-Y.An et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat6576ON THE COVERThe human brain is the product of myriad molecu-lar and genetic interactions.Here,a neon brain illustra-tion represents individual genetic variability,some of which may lead to disease(denoted by dim or dark segments),as investigated by the PsychENCODE Consortium.This issue sheds light on neurogenetic and epigenetic varia-tion in developing and adult neurotypical brains,as well as in schizophrenia,autism spectrum disorder,and bipolar disorder.See page 1262.Illustration:V.Altounian/ScienceILLUMINATING THE BRAINSEE ALSO SCI.TRANSL.MED.10.1126/scitranslmed.aat8178 SCI.TRANSL.MED.10.1126/scitranslmed.aat6912 SCI.ADV.10.1126/sciadv.aav8550 NEWS STORY P.12271226 SPACE LASER TO MAP TREES IN 3DGEDI data will yield maps of forest carbon and biodiversity By G.Popkin1227 HUMAN BRAIN SAMPLES YIELD A GENOMIC TROVERegulatory DNA take center stage in search for mechanisms of disease By K.Servick ILLUMINATING THE BRAIN SECTION P.12621228 BIOELECTRONICS THAT VANISH IN THE BODYWire-free devices that dissolve could expand the use of electric pulses in medicine By R.F.Service1229 WHY MODERN HUMANS HAVE ROUND HEADSNeanderthal DNA points to genes that influence brain By A.Gibbons PODCAST1229 CONFERENCES SCORE WELL ON CHILD CAREMale-dominated disciplines lead the pack By K.LanginFEATURE 1230 STARRY EYESNASA is planning four of the largest space telescopes ever.But which one will fly?By D.CleryINSIGHTSPOLICY FORUM 1236 TRAGEDY REVISITED EDITORIAL P.1217;PERSPECTIVE P.1242;PODCASTPERSPECTIVES 1242 REIMAGINING THE HUMANA human-centric worldview is blinding humanity to the consequences of our actions By E.Crist EDITORIAL P.1217;POLICY FORUM P.12361244 PRINTING NANOMATERIALSIN SHRINKING GELSPhotopatterning of reactive sites in gels enables arbitrary patterning of nanoparticles By T.E.Long and C.B.Williams REPORT P.1281Published by AAASon December 18,2018 http:/science.sciencemag.org/Downloaded from GRAPHIC:N.DESAI/SCIENCE;PHOTO:FABIO DE OLIVEIRA FREITAS14 DECEMBER 2018 VOL 362 ISSUE 6420 1213SCIENCE sciencemag.orgCONTENTS14 DECEMBER 2018 VOLUME 362 ISSUE 6420RESEARCHIN BRIEF 1259 From Science and other journalsRESEARCH ARTICLE 1271 SUPERCONDUCTIVITYRevealing hidden spin-momentum locking in a high-temperature cuprate superconductor K.Gotlieb et al.REPORTS 1276 ELECTROCATALYSISUltralow-loading platinum-cobalt fuel cell catalysts derived from imidazolate frameworks L.Chong et al.1281 3D PRINTING3D nanofabrication by volumetric deposition and controlled shrinkage of patterned scaffolds D.Oran et al.PERSPECTIVE P.12441285 ENZYMOLOGYEvolution of a highly active and enantiospecific metalloenzyme from short peptides S.Studer et al.1289 CHEMICAL PHYSICSObservation of the geometric phase effect in the H+HD W H2+D reaction D.Yuan et al.1293 RADIOCARBONAtmospheric 14C/12C changes during the last glacial period from Hulu Cave H.Cheng et al.1297 ARCHAEOLOGY1.9-million-