Science 2018-07-27.pdf

CREDITS:(CLOCKWISE FROM TOP)C.BICKEL/SCIENCE;MATTHIEU PALEY/NATIONAL GEOGRPAHIC CREATIVE;ANDY POTTS27 JULY 2018 VOL 361 ISSUE 6400 307SCIENCE sciencemag.org27 JULY 2018 VOLUME 361 ISSUE 6400CONTENTSINTRODUCTION 342 Marvelous Models M.Funk et al.NEWS 344 The Earth Machine P.VoosenREVIEWS348 Toward a predictive theory of correlated materials P.R.C.Kent and G.Kotliar355 Biophysical experiments and biomolecular simulations:A perfect match?S.Bottaro and K.Lindorff-Larsen360 Inverse molecular design using machine learning:Generative models for matter engineering B.Sanchez-Lengeling and A.Aspuru-Guzik366 Fundamentals of numerical relativity for gravitational wave sources B.BrgmannON THE COVERStrobe-lit view of the Summit supercomputer,capable of a peak perfor-mance of 200 petaflops,at the U.S.Department of Energys Oak Ridge National Laboratory.Widespread advances in computing power and algorithm development have greatly enhanced modeling capabilities in astronomy,physics,chemistry and materials science,and biology.See the special section starting on page 342.Photo:Carlos Jones,courtesy of ORNL;Creative Services:Renee Manning,courtesy of ORNLSEE ALSO EDITORIAL P.313 PERSPECTIVE P.326INSIGHTSPERSPECTIVES 326 REDUCING UNCERTAINTIES IN CLIMATE MODELSImplementing accurate calculations of radiative forcing can improve climate projections By B.J.Soden et al.SPECIAL SECTION P.342328 NEUROTECHNOLOGY TO ADDRESS BIG QUESTIONSProfiling of single neurons in tissue allows structure and function linkage in brain circuits By T.Knpfel RESEARCH ARTICLE P.380329 DYNAMIC CONDENSATESACTIVATE TRANSCRIPTIONTranscriptional components exhibit transient phase separation to drive gene activation By A.J.Plys and R.E.Kingston RESEARCH ARTICLES PP.378&379;REPORT P.412331 HYDROCARBON SYNTHESIS WITH VINYL CATIONSCatalytic generation of vinyl cations enables synthesis of functionalized hydrocarbons By S.H.Kennedy and D.A.Klumpp RESEARCH ARTICLE P.381NEWSIN BRIEF314 News at a glanceIN DEPTH 316 REPORT DETAILS HARASSMENT BY FAMED BIOLOGIST Allegations that felled Francisco Ayala divide scientists,university community By M.Wadman317 ELECTRON-ION COLLIDER WINS KEY ENDORSEMENTNational Academies report calls for accelerator to look inside protons and neutrons By A.Cho318 STUDY OF SEA NOMADS UNDER FIRE IN INDONESIACritics say study lacked local ethical approval and role for Indonesian experts By D.Rochmyaningsih320 LAKE SPIED DEEP BELOW POLAR ICE CAP ON MARSOrbiting radar instrument finds martian analog to pools under Antarctic glaciers By D.Clery REPORT BY R.OROSEI ET AL.10.1126/SCIENCE.AAR7268;PERSPECTIVE BY A.DIEZ 10.1126/SCIENCE.AAU1829;PODCAST321 CHIPMAKERS LOOK PAST MOORES LAW,AND SILICONNovel computer chip materials explored in$1.5 billion U.S.military research program By R.F.ServiceSPECIAL SECTIONFrontiers in ComputationFEATURE 322 THE TRAILBLAZERJoanna Harper is racing to reveal how a gender transition alters an athletes physiology and performance By K.Kornei PODCAST318328&380Mapping cells in tissue DA_0727TOC.indd 3077/25/18 11:54 AMPublished by AAASon July 29,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(FROM TOP)ADAPTED FROM SHAW NIELSEN/THE ISPOT;KRIS WIKTOR/SHUTTERSTOCK.COM27 JULY 2018 VOL 361 ISSUE 6400 309SCIENCE sciencemag.orgCONTENTS27 JULY 2018 VOLUME 361 ISSUE 6400RESEARCHIN BRIEF 375 From Science and other journalsRESEARCH ARTICLES MOLECULAR BIOLOGY378 Imaging dynamic and selective low-complexity domain interactions that control gene transcription S.Chong et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aar2555379 Coactivator condensation at super-enhancers links phase separation and gene control B.R.Sabari et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aar3958 PERSPECTIVE P.329;REPORT P.380380 BIOTECHNOLOGYThree-dimensional intact-tissue sequencing of single-cell transcriptional states X.Wang et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat5691 PERSPECTIVE P.328381 ORGANIC CHEMISTRYTeaching an old carbocation new tricks:Intermolecular CH insertion reactions of vinyl cations S.Popov et al.PERSPECTIVE P.331REPORTS 387 DEVICE TECHNOLOGYDirac-source field-effect transistors as energy-efficient,high-performance electronic switches C.Qiu et al.392 NEUROSCIENCEThe hippocampal engram maps experience but not place K.Z.Tanaka et al.398 EUSOCIALITYSocial regulation of insulin signaling and the evolution of eusociality in ants V.Chandra et al.402 GUT INFLAMMATIONLectins modulate the microbiota of social amoebae C.Dinh et al.406 GUT INFLAMMATIONLKB1 deficiency in T cells promotes the development of gastrointestinal polyposis M.C.Poffenberger et al.PERSPECTIVE P.332412 MOLECULAR BIOLOGYMediator and RNA polymerase II clusters associate in transcription-dependent condensates W.-K.Cho et al.PERSPECTIVE P.329;RESEARCH ARTICLES PP.378&379SCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancemen