CREDITS:(CLOCKWISEFROMTOP)C.BICKEL/SCIENCE;MATTHIEUPALEY/NATIONALGEOGRPAHICCREATIVE;ANDYPOTTS27JULY2018•VOL361ISSUE6400307SCIENCEsciencemag.org27JULY2018•VOLUME361•ISSUE6400CONTENTSINTRODUCTION342MarvelousModelsM.Funketal.NEWS344TheEarthMachineP.VoosenREVIEWS348TowardapredictivetheoryofcorrelatedmaterialsP.R.C.KentandG.Kotliar355Biophysicalexperimentsandbiomolecularsimulations:Aperfectmatch?S.BottaroandK.Lindorff-Larsen360Inversemoleculardesignusingmachinelearning:GenerativemodelsformatterengineeringB.Sanchez-LengelingandA.Aspuru-Guzik366FundamentalsofnumericalrelativityforgravitationalwavesourcesB.BrügmannONTHECOVERStrobe-litviewoftheSummitsupercomputer,capableofapeakperfor-manceof200petaflops,attheU.S.DepartmentofEnergy’sOakRidgeNationalLaboratory.Widespreadadvancesincomputingpowerandalgorithmdevelopmenthavegreatlyenhancedmodelingcapabilitiesinastronomy,physics,chemistryandmaterialsscience,andbiology.Seethespecialsectionstartingonpage342.Photo:CarlosJones,courtesyofORNL;CreativeServices:ReneeManning,courtesyofORNLSEEALSO▶EDITORIALP.313▶PERSPECTIVEP.326INSIGHTSPERSPECTIVES326REDUCINGUNCERTAINTIESINCLIMATEMODELSImplementingaccuratecalculationsofradiativeforcingcanimproveclimateprojectionsByB.J.Sodenetal.▶SPECIALSECTIONP.342328NEUROTECHNOLOGYTOADDRESSBIGQUESTIONSProfilingofsingleneuronsintissueallowsstructureandfunctionlinkageinbraincircuitsByT.Knöpfel▶RESEARCHARTICLEP.380329DYNAMICCONDENSATESACTIVATETRANSCRIPTIONTranscriptionalcomponentsexhibittransientphaseseparationtodrivegeneactivationByA.J.PlysandR.E.Kingston▶RESEARCHARTICLESPP.378&379;REPORTP.412331HYDROCARBONSYNTHESISWITHVINYLCATIONSCatalyticgenerationofvinylcationsenablessynthesisoffunctionalizedhydrocarbonsByS.H.KennedyandD.A.Klumpp▶RESEARCHARTICLEP.381NEWSINBRIEF314NewsataglanceINDEPTH316REPORTDETAILSHARASSMENTBYFAMEDBIOLOGISTAllegationsthatfelledFranciscoAyaladividescientists,universitycommunityByM.Wadman317ELECTRON-IONCOLLIDERWINSKEYENDORSEMENTNationalAcademiesreportcallsforacceleratortoloo...