Science 2016-11-04.pdf

4 NOVEMBER 2016 VOL 354 ISSUE 6312 523SCIENCE sciencemag.org4 NOVEMBER 2016 VOLUME 354 ISSUE 6312CONTENTS547Birds in troubleSPECIAL SECTIONPain researchINSIGHTSPERSPECTIVES 544 BUILDING BRIDGES TO REGENERATE AXONSA secreted factor stimulates glia to mend spinal cord injury By P.R.Williams and Z.He REPORT P.630546 A TESTING TIME FOR ANTIMATTERPrecision measurement of antiprotonic helium provides a test of physical laws By W.Ubachs REPORT P.610547 MIGRATORY BIRDS UNDER THREATHabitat degradation and loss,illegal killings,and climate change threaten European migratory bird populations By F.Bairlein549 HOW TOBACCO SMOKE CHANGES THE(EPI)GENOMEDistinct mutation types are found in diverse cancers associated with smoking By G.P.Pfeifer REPORT P.618550 DEEP-SEA CORALS FEEL THE FLOWUranium isotope data from deep-water corals help to resolve conflicting results from shallow-water corals By Y.Yokoyama and T.M.Esat REPORT P.626552 TIPS FOR BATTLING BILLION-DOLLAR BEETLESTiny insecticidal proteins(Tips)kill pests that evolved resistance to engineered corn By B.E.Tabashnik REPORT P.634553 A RADICAL APPROACH TOPOSTTRANSLATIONAL MUTAGENESISIntroducing diverse protein side chains via carbon-carbon bond-forming reactions By R.Hofmann and J.W.Bode RESEARCH ARTICLE P.597;REPORT P.623POLICY FORUM555 WATER STRATEGIES FORTHE NEXT ADMINISTRATIONWater policy offers opportunity for nonpartisan agreement By P.H.GleickNEWSIN BRIEF530 News at a glanceIN DEPTH 533 SEA ICE SHRINKS IN STEP WITH CARBON EMISSIONSModels may underestimate the pace of ice loss because they are missing Arctic warming By W.Cornwall REPORT BY D.NOTZ ET AL.10.1126/science.aag2345534 AMBITIOUS WEB FUNDRAISING STARTUP FAILS TO MEET BIG GOALSHundreds of scientists paid fees to have their work featured on Benefunder,but very few received donations By M.Harris535 CONTROVERSIAL HIV VACCINE STRATEGY GETS A SECOND CHANCEModest success in Thailand inspires South Africa trial By J.Cohen536 FOUR-LEGGED SNAKE MAY BE ANCIENT LIZARD INSTEADControversy swirls around fossil,which is no longer accessible By C.Gramling537 DATA CHECK:CALIFORNIA RULES U.S.CORPORATE RESEARCHSurvey shows California has widened its lead in state-by-state analysis of what companies spend on research By J.MervisFEATURES 538 MICE MADE EASYThe genome-editing tool CRISPR upends the vital business of creating mutant mice By J.Cohen541 A reporter does CRISPRBy J.Cohen VIDEOON THE COVERA woman holds her hand in ice water,one of sev-eral techniques used to measure pain tolerance.Typically,healthy people can submerge their hands for up to 5 minutes.However,for some of those taking opioids,10 to 15 seconds is the limit,suggesting opioid-induced hypersensitivity to pain.For more on recent develop-ments in pain research,see the special section beginning on page 564.Photo:Matthew RakolaINTRODUCTION 564 The future of pain researchNEWS566 Pot and pain By G.Miller569 Primed for pain By K.ServickREVIEWS572 Pain regulation by non-neuronal cells and inflammation R.-R.Ji et al.578 Neural circuits for pain:Recent advances and current views C.Peirs and R.P.Seal584 Deconstructing the sensation of pain:The influence of cognitive processes on pain perception K.Wiech588 Exploring pain patho-physiology in patients C.SommerSEE ALSO EDITORIAL P.529 PODCAST VIDEO53354BirBirds DA_1104TOC.indd 52311/2/16 10:44 AMPublished by AAAS on November 10,2016http:/science.sciencemag.org/Downloaded from PHOTO:SINATRA ET AL.4 NOVEMBER 2016 VOL 354 ISSUE 6312 525SCIENCE sciencemag.orgCONTENTS599Protein mutations that rescue defects4 NOVEMBER 2016 VOLUME 354 ISSUE 6312RESEARCHIN BRIEF 593 From Science and other journalsRESEARCH ARTICLES 596 SCIENCE COMMUNITYQuantifying the evolution of individual scientific impact R.Sinatra et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf5239597 CHEMICAL BIOLOGYPosttranslational mutagenesis:A chemical strategy for exploring protein side-chain diversity T.H.Wright et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aag1465 PERSPECTIVE P.553;REPORT P.623598 SYSTEMS BIOLOGYA transcription factor hierarchy defines an environmental stress response network L.Song et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aag1550599 YEAST GENETICSExploring genetic suppression interactions on a global scale J.van Leeuwen et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aag0839REPORTS 600 OPTICSMicroresonator soliton dual-comb spectroscopy M.-G.Suh et al.603 OPTICAL PROCESSINGA coherent Ising machine for 2000-node optimization problems T.Inagaki et al.REPORT P.614606 QUANTUM GASESUniversal space-time scaling symmetry in the dynamics of bosons across a quantum phase transition L.W.Clark et al.610 PHYSICSBuffer-gas cooling of antiprotonic helium to 1.5 to 1.7 K,and antiproton-to-electron mass ratio M.Hori et al.PERSPECTIVE P.546614 OPTICAL PROCESSINGA fully programmable 100-spin coherent Ising machine with all-to-all connections P.L.McMahon et al.