CREDITS:(TOPTOBOTTOM)KELLIEHOLOSKI/SCIENCEFROMA.DAVIDSON;ISABELHOLGUERA,CLAUDEDESPLANLABORATORY;PIERREHUGUET/SCIENCESOURCE12OCTOBER2018•VOL362ISSUE6411125SCIENCEsciencemag.org12OCTOBER2018•VOLUME362•ISSUE6411CONTENTS152&207GeneswappinginbacteriaINTRODUCTION170Mind-bogglingbraindevelopmentNEWS172AfragileexistenceByH.Furfaro▶PODCASTREVIEWS176NeuronalspecificationinspaceandtimeI.HolgueraandC.Desplan181GliaasarchitectsofcentralnervoussystemformationandfunctionN.J.AllenandD.A.Lyons185Microgliaandearlybraindevelopment:AnintimatejourneyM.S.Thionetal.190Homology,neocortex,andtheevolutionofdevelopmentalmechanismsS.D.BriscoeandC.W.RagsdaleINSIGHTSPERSPECTIVES148ANALTERNATIVEURBANGREENCARPETHowcanwemovetosustainablelawnsinatimeofclimatechange?ByM.IgnatievaandM.Hedblom▶PODCAST150NEXT-GENERATIONSELF-HEALINGMATERIALSAdjustingmolecularstructuretacklesalong-standingproblemofsyntheticmateriallongevityByB.S.Sumerlin▶REPORTP.220151DIMERIZATIONQUALITYCONTROLVIAUBIQUITYLATIONAspecializedubiquitinligaseenzymeapprovesonlyfunctionaldimersByL.HerhausandI.Dikic▶RESEARCHARTICLEP.198152ACOMMONTRICKFORTRANSFERRINGBACTERIALDNAAknownvirus-mediatedprocessspreadsbacterialgenesmorethanexpectedByA.R.Davidson▶RESEARCHARTICLEP.207154TREGCELLS—THENEXTFRONTIEROFCELLTHERAPYWillregulatoryTcellsbeafrontlinetherapyforautoimmunityandotherdiseases?ByJ.A.BluestoneandQ.Tang156ANTI-CRISPRSONTHEMARCHThediversityofanti-CRISPRproteinsencodedbyvirusesisrapidlyexpandingByE.V.KooninandK.S.Makarova▶REPORTSPP.236&240157EASYACCESSTOELUSIVERADICALREACTIONSTwomildapproachesgenerateradicalintermediatesfrommaskedaldehydesByJ.M.BlackburnandJ.L.Roizen▶REPORTP.225POLICYFORUM159RETURNOFRESULTSANDDATATOSTUDYPARTICIPANTSArecentreporturgesprogressbutbuildsbarrierstoresearchparticipants’accessByS.M.WolfandB.J.EvansONTHECOVERNeuronsofthebrainfindtheirplacesduringdevelopmentguidedbyinternalprogramsandexternalinterac-tions.ThisconfocalmicroscopyimagefromaDrosophilalarvashowsthecharacteristicplacementofneuronsintheopticlob...
