Science 2016-08-12.pdf

12 AUGUST 2016 VOL 353 ISSUE 6300 623SCIENCE sciencemag.org12 AUGUST 2016 VOLUME 353 ISSUE 6300CONTENTS647&708Targeting amyotrophic lateral sclerosisNEWSIN BRIEF628 News at a glanceIN DEPTH 632 FOUNDERS DEATH UNSETTLES EGYPTS SCIENCE CITYNobel Prizewinning chemist Ahmed Zewail was key to fundraising and recruitment By R.F.Service633 CAN CAPTIVE BREEDING SAVE MEXICOS VAQUITA?Scientists mull a risky strategy to save an imperiled porpoise By B.Goldfarb634 NIH PLANS TO FUND HUMAN-ANIMAL CHIMERA RESEARCHAgency would subject experimentssuch as growing human organs in pigsto extra ethical review By J.Kaiser635 PARTICLE NO-SHOW AT LHC PROMPTS ANXIETYAccelerator enters prime discovery phase,but the clock is ticking By A.Cho637 SCIENTISTS SPLIT ON OREGON OLD-GROWTH FOREST PLANThe northern spotted owl is again the center of controversy By W.CornwallScience Staff.626New Products.713Science Careers.714INSIGHTSPERSPECTIVES 644 MAKING SENSE OF THE EXOPLANET ZOOThe diversity of substellar objects may call for a rethinking of our labeling conventions By R.Oppenheimer RESEARCH ARTICLE P.673646 TWISTS AND TURNS IN GATING ION CHANNELS WITH VOLTAGEThe EAG potassium channel may use an alternative voltage-dependent gating mechanism By G.E.S.Toombes and K.J.Swartz RESEARCH ARTICLE P.664647 ONE TARGET FOR AMYOTROPHICLATERAL SCLEROSIS THERAPY?Targeting a single protein reduces both toxic repeat RNAs and proteins By S.Mizielinska and A.M.Isaacs REPORT P.708648 MEASURING THE PASSAGE OF BRAIN TIMEMany brain areas are under both circadian and homeostatic control By C.A.Czeisler REPORT P.687650 ATMOSPHERIC RADICAL CHEMISTRY REVISITEDSunlight may directly drive previously unknown organic reactions at environmental surfaces By V.Vaida REPORT P.699651 BALANCING ECONOMIC AND ECOLOGICAL GOALSWhat are the trade-offs between economic development and ecosystem conservation?By E.G.Frank and W.SchlenkerPOLICY FORUM653 THE CHALLENGE OF CLIMATE-CHANGE NEOSKEPTICISMDecision science and risk management are underutilized By P.C.Stern et al.AM M641653FEATURES 638 FROM BARK TO BEDSIDEClinical trials in pets are ramping up,but will they benefit human health?By D.Grimm641 OIL IN THE FORESTA rash of spills in the Amazon has scientists and villagers scrambling to understand oils effects on the ecosystem By B.FraserPublished by AAAS on August 29,2016http:/science.sciencemag.org/Downloaded from 12 AUGUST 2016 VOL 353 ISSUE 6300 625SCIENCE sciencemag.orgCONTENTS646&664A variation on channel gating12 AUGUST 2016 VOLUME 353 ISSUE 6300RESEARCHIN BRIEF 660 From Science and other journalsREVIEW663 ZIKAAssessing the global threat from Zika virus J.Lessler et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf8160RESEARCH ARTICLES 664 STRUCTURAL BIOLOGYStructure of the voltage-gated K+channel Eag1 reveals an alternative voltage sensing mechanism J.R.Whicher and R.MacKinnon PERSPECTIVE P.646669 PHYSICSLaser spectroscopy of muonic deuterium R.Pohl et al.673 EXTRASOLAR PLANETSDirect imaging discovery of a Jovian exoplanet within a triple-star system K.Wagner et al.PERSPECTIVE P.644699 ATMOSPHERIC CHEMISTRYAtmospheric photochemistry at a fatty acidcoated air-water interface S.Rossignol et al.PERSPECTIVE P.650702 LIFE HISTORYEye lens radiocarbon reveals centuries of longevity in the Greenland shark(Somniosus microcephalus)J.Nielsen et al.PODCAST705 HYDROLOGYContinental patterns of submarine groundwater discharge reveal coastal vulnerabilities A.H.Sawyer et al.708 NEURODEGENERATIONSpt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts N.J.Kramer et al.PERSPECTIVE P.647ON THE COVERA Greenland shark(Somniosus microcephalus).These creatures are among the worlds largest carnivorous sharks and are distributed throughout Arctic waters.For decades,the longevity of this slow-growing species has remained a mystery.Using well-established radiocarbon dating techniques applied on Greenland shark eye lens tissue,Nielsen et al.estimate that these animals are the longest-living vertebrates known to date.See page 702.Photo:Nick Caloyianis/National Geographic CreativeSCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2016 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership and subscription(51 issues):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1522;Foreign postage extra:Mexico,Caribbean(surface mail)$55;other countries(air assist delivery)$89.First class,airmail,student,and emeritus rates on request.Canadian rates with GST available upon request,GST#1254 88122.Publications Mail Agreement Number 1069624.Printed in the U.S.A.Change of address:Allow 4 weeks,giving old and