Science 2018-08-10.pdf

CREDITS:(TOP TO BOTTOM)C.BICKEL/SCIENCE;EPHOTOCORP/ALAMY STOCK PHOTO;JENA ARDELL/GETTY IMAGES10 AUGUST 2018 VOL 361 ISSUE 6402 527SCIENCE sciencemag.org10 AUGUST 2018 VOLUME 361 ISSUE 6402CONTENTSINSIGHTSPERSPECTIVES 546 MEASURING EARTHS RIVERSSatellite images enable global tally of freshwater ecosystems and resources By M.Palmer and A.Ruhi REPORT P.585548 PHASE CHANGES IN NEUROTRANSMISSIONSynaptic vesicles cluster by partitioning into phase-separated condensates By E.E.Boczek and S.Alberti REPORT P.604549 ULTRAHIGH THERMAL CONDUCTIVITYCONFIRMED IN BORON ARSENIDEHigh-quality crystals minimize conductivity losses caused by phonon scattering at defects By C.Dames REPORTS PP.575,579,&582551 TIGHTER LYMPHATIC JUNCTIONS PREVENT OBESITYZippering of cellular junctions in intestinal lacteals prevents fat uptake By D.M.McDonald REPORT P.599552 THE FUTURE OF HUMANS AS MODEL ORGANISMSA“human phenomic science”approach could accelerate personalized medicine By G.FitzGerald et al.POLICY FORUM 554 BUILDING AN EVIDENCE BASEFOR STAKEHOLDER ENGAGEMENTThe private sector provides lessons and models By J.V.LaveryBOOKS ET AL.558 TURN IT UPScience meets metal in a musical introduction to modern physics By D.J.Reilly559 LATERAL MOVESAn engaging history reveals the scientific struggle to understand horizontal gene transfer By I.T.Knight542Pests in the making:young brown marmorated stinkbugs and eggs558548&604Condensing synaptic vesicles in neurotransmission541 INFRARED METHOD COULD SAFELY IDENTIFY CELLSResearchers use powerful synchrotron radiation to profile cell types By M.LeslieFEATURE 542 CONTROL FREAKSImporting an exotic species for pest control takes years of preparation.What happens when it arrives on its own?By K.Servick PODCASTNEWSIN BRIEF534 News at a glanceIN DEPTH 537 NEW GEOLOGICAL AGE COMES UNDER FIRETiming and extent of ancient drought used to define the Meghalayan are uncertain By P.Voosen PODCAST538 MARCH OF DIMES CURTAILS SUPPORT FOR RESEARCHERSCuts at historic nonprofit leave grantees fuming By K.Servick539 HYBRIDS SPAWNED LAKE VICTORIAS RICH FISH DIVERSITYCichlid speciation helped by pre-existing genetic variation By E.Pennisi540 HOPE BLOOMS FOR HAWAIIS ICONIC NATIVE TREESome ohia trees resist foreign fungiand fencing out animals can also protect the trees from fatal infections By E.PennisiDA_0810TOC.indd 5278/8/18 11:49 AMPublished by AAASon August 14,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(ILLUSTRATION)TAI11/SHUTTERSTOCK;(PHOTO):ISTOCK.COM/YURIYVLASENKO10 AUGUST 2018 VOL 361 ISSUE 6402 529SCIENCE sciencemag.orgCONTENTS10 AUGUST 2018 VOLUME 361 ISSUE 6402RESEARCHIN BRIEF 564 From Science and other journalsREVIEW567 OPTICSDissipative Kerr solitons in optical microresonators T.J.Kippenberg et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aan8083RESEARCH ARTICLES 568 STRUCTURAL BIOLOGYStructural basis for the recognition of Sonic Hedgehog by human Patched1 X.Gong et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aas8935569 ORGANIC CHEMISTRYMapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS S.Lin et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aar6236570 2D MATERIALSThe role of electron-electron interactions in two-dimensional Dirac fermions H.-K.Tang et al.REPORTS THERMAL CONDUCTIVITY575 Experimental observation of high thermal conductivity in boron arsenide J.S.Kang et al.579 High thermal conductivity in cubic boron arsenide crystals S.Li et al.582 Unusual high thermal conductivity in boron arsenide bulk crystals F.Tian et al.PERSPECTIVE P.549585 RIVER NETWORKSGlobal extent of rivers and streams G.H.Allen and T.M.Pavelsky PERSPECTIVE P.546588 NEUROSCIENCEOpioid prescribing decreases after learning of a patients fatal overdose J.N.Doctor et al.591 EVOLUTIONAncient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals W.K.Meyer et al.594 KIDNEY CANCERSingle-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors M.D.Young et al.599 METABOLISMLacteal junction zippering protects against diet-induced obesity F.Zhang et al.PERSPECTIVE P.551604 CELL BIOLOGYA liquid phase of synapsin and lipid vesicles D.Milovanovic et al.PERSPECTIVE P.548607 SIGNAL TRANSDUCTIONApoptosis propagates through the cytoplasm as trigger waves X.Cheng and J.E.Ferrell Jr.ON THE COVERIguaz Falls,Earths largest waterfall system,on the Iguaz River between Argentina and Brazil.Earths turbulent rivers and streams are natural hotspots for atmospheric exchange.Thousands of satellite images have revealed that rivers and streams cover nearly 45%more of the worlds surface than previous spatial estimates,indicating that these water bodies contribute more to atmospheric concentrations of greenhouse gas than previously thought.See pages 546 and 585.Photo:Inge Johnsson/Alamy Stock PhotoSCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American A