Science 2018-03-23.pdf

GRAPHIC(TOP):A.KITTERMAN/SCIENCE;ILLUSTRATION:DANIEL HERTZBERG 23 MARCH 2018 VOL 359 ISSUE 6382 1301SCIENCE sciencemag.org23 MARCH 2018 VOLUME 359 ISSUE 6382CONTENTS1334&1391Electron transport in radical polymers NEWSIN BRIEF1310 News at a glanceIN DEPTH 1314 U.K.ATTACK PUTS NERVE AGENT IN SPOTLIGHTResearchers race to understand deadly compound developed by Soviet scientists By R.Stone1315 ACCOUNTING RULES HOBBLE SPANISH INSTITUTESStaff at centers for solar energy research and oceanography raise alarm By T.Rabesandratana1316 HAWKINGS BID TO SAVE QUANTUM THEORY FROM BLACK HOLESHe struggled to explain why black holes dont destroy information,a puzzle that may be his greatest legacy By A.Cho1317 Stephen Hawking,betting manBy D.Clery1318 PROTEIN MAY EXPLAIN MORNING SICKNESS,AND WORSETwo groups point to a possible trigger for vomiting,nausea By R.Dengler1319 A RESEARCH BEHEMOTH IS BORN IN BRITAINExpectations are high for the new 6 billion funder,UK Research and Innovation By E.StokstadFEATURES 1320 THE REALISTVaclav Smil looks to history for the future of energy.What he sees is sobering By P.VoosenINTRODUCTION 1344 The cancer immunotherapy revolutionNEWS1346 Too much of a good thing?J.Kaiser1348 Sticker shock J.Couzin-FrankelRESEARCH 1350 Cancer immunotherapy using checkpoint blockade A.Ribas and J.D.Wolchok1355 Personalized vaccines for cancer immunotherapy U.Sahin and.Treci1361 CAR T cell immunotherapy for human cancer C.H.June et al.1366 The microbiome in cancer immunotherapy:Diagnostic tools and therapeutic strategies L.Zitvogel et al.SPECIAL SECTIONCancer immunotherapyON THE COVERArtists rendering of a patient receiving personalized treatment for cancer.With the help of newly developed immunotherapies,a growing number of patients are partners in their own treatment.For more on techniques and strategies for cancer immunotherapy,see page 1344.Illustration:Daniel HertzbergINSIGHTSPERSPECTIVES 1328 ARE WOOD PELLETS A GREEN FUEL?A return to firewood is bad for forests and for the climate By W.H.Schlesinger1330 EARLY LIFE EXPERIENCE SHAPES NEURAL GENOMETransposons accumulate in neurons of pups with lack of maternal care in mice By S.Song and J.G.Gleeson REPORT P.13951331 RNA TARGETING ANDTRANSLATION IN AXONSLocal translation of transcripts takes center stage in neuron growth and regeneration By A.Riccio REPORT P.14161333 FROM ROCK-STABLE TO REACTIVE PHOSPHORUSA low-temperature route converts phosphate into an anion useful in chemical synthesis By J.D.Protasiewicz REPORT P.13831334 A RADICAL ADVANCE FOR CONDUCTING POLYMERSOrganic radical polymers can have much higher electrical conductivities than anticipated By J.Lutkenhaus REPORT P.13911335 TARGETING ANGIOGENIC METABOLISM IN DISEASETargeting endothelial cell metabolism offers new therapeutic opportunities for various conditions By X.Li and P.CarmelietPOLICY FORUM 1337 EXPANDED HEALTH SYSTEMS FOR SUSTAINABLE DEVELPMENTAdvance transformative research for the 2030 agenda By C.DyeDA_0323TOC.indd 13013/21/18 11:03 AMPublished by AAASon March 25,2018 http:/science.sciencemag.org/Downloaded from PHOTO:REZUS/ISTOCKPHOTO.COM;GRAPHIC:V.ALTOUNIAN/SCIENCE23 MARCH 2018 VOL 359 ISSUE 6382 1303SCIENCE sciencemag.orgCONTENTS1330&1395Maternal care and genome plasticity 23 MARCH 2018 VOLUME 359 ISSUE 63821391 CONDUCTING POLYMERSA nonconjugated radical polymer glass with high electrical conductivity Y.Joo et al.PERSPECTIVE P.13341395 NEURODEVELOPMENTEarly life experience drives structural variation of neural genomes in mice T.A.Bedrosian et al.PERSPECTIVE P.1330;PODCAST1399 PLANT SCIENCEA single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus W.Sakulkoo et al.CANCER 1403 Lymph node metastases can invade local blood vessels,exit the node,and colonize distant organs in mice E.R.Pereira et al.1408 Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice M.Brown et al.1411 BIOCHEMISTRYThe biosynthesis of methanobactin G.E.Kenney et al.1416 CELL BIOLOGYLocally translated mTOR controls axonal local translation in nerve injury M.Terenzio et al.PERSPECTIVE P.1331SCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2018 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership,including subscription(12 months):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1808;Foreign postage extra:Mexico,Caribbean(surface mail)$55;other countries(air assist delivery):$89.First class,airmail,student,and emeritus rates on request.Canadian rates with GST available upon request,GST#125488122.Publications Mail Agreement Number 1069624.Printed in the U.S.A.Change of address:Allow 4 w