Science 2018-07-06.pdf

CREDITS:(FROM TOP)C.BICKEL/SCIENCE;STEPHAN SCHMITZ6 JULY 2018 VOL 361 ISSUE 6397 3SCIENCE sciencemag.org6 JULY 2018 VOLUME 361 ISSUE 6397CONTENTS33Inheriting histone modificationsNEWSIN BRIEF8 News at a glanceIN DEPTH 10 POLIO OUTBREAKS IN THE DRC THREATEN ERADICATION EFFORTVaccine-derived virus spreads despite emergency response By L.Roberts PODCAST11 LAWMAKERS ASK NIH AND CDC CHARITIES FOR MORE ON DONORSCongressional panel seeks greater transparency on private donations to foundations that aid federal research By J.Mervis12 OPTICAL INTERFEROMETERS SHARPEN VIEWS OF THE SKYIn New Mexico,a renewed attempt to build an optical array could bring spy satellites into focus By A.Mann14 BIOLOGISTS RAISE ALARM OVER CHANGES TO BIOPIRACY RULESPlan would bring genetic sequences under Nagoya Protocol By K.KupferschmidtINSIGHTSBOOKS ET AL.22 STEMM EDUCATION SHOULD GET“HACD”Incorporating humanties,arts,crafts,and design into curricula makes better scientists By R.Root-Bernstein LETTERS P.24LETTERS 24 NEXTGEN VOICES:BROAD INTERESTS REAP BENEFITS FOR SCIENCE BOOKS ET AL.P.2215 PROPOSED DOE TEST REACTOR SPARKS CONTROVERSYCongress favors the Versatile Fast Neutron Source but some scientists see little need By A.ChoFEATURES 16 HIDDEN CONFLICTS?An investigation finds a pattern of after-the-fact compensation by pharma to those advising the U.S.government on drug approvals By C.Piller21 Is FDAs revolving door open too wide?By C.Piller16PERSPECTIVES 27 AMERICAS LOST DOGSThe dogs that arrived in the Americas with human settlers 10,000 years ago left almost no genetic traces By L.Goodman and E.K.Karlsson REPORT P.8129 A NEW BRAIN CIRCUIT IN FEEDING CONTROLComponents of a neural circuit that regulates body weight are found By S.Diano REPORT P.7630 MOLECULAR MOVIES FILMED ATCONICAL INTERSECTIONSElectron diffraction maps atomic motions that result from photoexcitation of CF3I molecules By H.H.Fielding REPORT P.6431 THE SEARCH FOR ANCIENT DNA HEADS EASTMultiple migrations explain the peopling of Southeast Asia in the past 10,000 years By P.Bellwood REPORTS PP.88&9233 CHROMATIN DOMAINS RICH IN INHERITANCEOnly certain histone posttranslational modifications qualify as being epigenetic By D.Reinberg and L.D.ValesDA_0706TOC.indd 37/3/18 11:24 AMPublished by AAASon July 9,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(CLOCKWISE FROM TOP):J.YANG ET AL.;ROBERT NEUBECKER;BRENDON ROSE6 JULY 2018 VOL 361 ISSUE 6397 5SCIENCE sciencemag.orgCONTENTS30&64Watching a breakup 6 JULY 2018 VOLUME 361 ISSUE 6397RESEARCHIN BRIEF 38 From Science and other journalsRESEARCH ARTICLES 41 STRUCTURAL BIOLOGYStructure basis for RNA-guided DNA degradation by Cascade and Cas3 Y.Xiao et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aat083942 ATMOSPHERIC CIRCULATIONAtmospheric blocking as a traffic jam in the jet stream N.Nakamura and C.S.Y.HuangREPORTS FRAMEWORK MATERIALS48 Single-crystal x-ray diffraction structures of covalent organic frameworks T.Ma et al.PERSPECTIVE P.3552 Seeded growth of single-crystal two-dimensional covalent organic frameworks A.M.Evans et al.57 QUANTUM OPTICSA single-photon switch and transistor enabled by a solid-state quantum memory S.Sun et al.60 QUANTUM INFORMATIONObservation of an environmentally insensitive solid-state spin defect in diamond B.C.Rose et al.64 CHEMICAL PHYSICSImaging CF3I conical intersection and photodissociation dynamics with ultrafast electron diffraction J.Yang et al.PERSPECTIVE P.3068 ORGANIC CHEMISTRYTandem catalysis for asymmetric coupling of ethylene and enynes to functionalized cyclobutanes V.V.Pagar and T.V.RajanBabu72 OCEAN CHEMISTRYBiological uptake and reversible scavenging of zinc in the global ocean T.Weber et al.76 NEUROSCIENCERegulation of feeding by somatostatin neurons in the tuberal nucleus S.X.Luo et al.PERSPECTIVE P.29DOMESTICATION81 The evolutionary history of dogs in the Americas M.N Leathlobhair et al.PERSPECTIVE P.2785 Ancient goat genomes reveal mosaic domestication in the Fertile Crescent K.G.Daly et al.HUMAN GENOMICS88 The prehistoric peopling of Southeast Asia H.McColl et al.92 Ancient genomes document multiple waves of migration in Southeast Asian prehistory M.Lipson et al.PERSPECTIVE P.31ON THE COVERAn analysis of pharma-ceutical payments to physicians after they voted on drug approval recommendations sug-gests that the Food and Drug Administration(FDA)needs to consider whether prospects of future rewards could influence its advisory panels.The investigation also indicates that the FDA may have missed more traditional conflicts of interest for those advisers.Another story looks at revolving-door concerns for FDA staff.See page 16.Illustration:Stephan SchmitzSCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2018 by