Science 2016-05-06.pdf

6 MAY 2016 VOL 352 ISSUE 6286 627SCIENCE sciencemag.org6 MAY 2016 VOLUME 352 ISSUE 6286CONTENTS658Personalized cancer immunotherapy NEWSIN BRIEF632 News at a glanceIN DEPTH 635 AMAZON RAINFOREST TO GET A GROWTH CHECKAmbitious experiment will test whether rising CO2 will boost the tropical carbon sink By D.Grossman636 MORE DELAYS FOR ITER,AS PARTNERS BALK AT COSTSReview warns that new timeline could still be too optimistic By D.Clery and A.Cho637 A REBOOT FOR WAVE ENERGYU.K.engineers and funders take stock of failures as they design new prototypes By E.Stokstad639 WHY HUMANS ARE THE HIGH-ENERGY APESOur metabolism runs faster than that of other apes,likely allowing us to evolve big brains By A.Gibbons640 HUMAN EMBRYO RESEARCH CONFRONTS ETHICAL RULETime to revise 14-day limit for growing IVF embryos?By P.MonahanINSIGHTSBOOKS ET AL.648 FIGHTING FOR OUR FUTUREPERSPECTIVES 654 MEASURING SLOW SLIP OFFSHOREMonitoring changes in the seafl oor might be used for earthquake and tsunami forecasting By A.M.Trhu REPORT P.701FEATURES 641 AN OASIS FOR ORCASAdvocates dream of fl ying killer whales to an ocean sanctuary,but does science support the move?By D.Grimm644 THE POWER OF PERSONALITYFrom birds to spiders,individuals exhibit consistent dif erences in behavior that shape the fate of their species By E.Pennisi PODCASTtk656 SELF-ASSEMBLY CREATES 2D MATERIALSCarefully chosen mixtures of polymers form rectangular platelets in solution By M.Ballauf REPORT P.697657 INSPIRED BY NATUREDesigned proteins have structural features resembling those of natural active sites By R.Netzer and S.J.Fleishman RESEARCH ARTICLE P.680;REPORT P.687658 THE“CANCER IMMUNOGRAM”Visualizing the state of cancerimmune system interactions may spur personalized therapy By C.U.Blank et al.644648661&708Science Staf .630New Products.730Science Careers.731661 HOPE FOR AMERICAS NEXT GENERATIONThe gap in survival rates for children in the richest and poorest U.S.communities has shrunk By M.J.Bailey and B.Timpe REPORT P.708663 WHY PURSUE THE POSTDOC PATH?Concise,diverse rationales require nuanced policies By H.Sauermann and M.RoachPublished by AAAS on May 5,2016http:/science.sciencemag.org/Downloaded from 6 MAY 2016 VOL 352 ISSUE 6286 629SCIENCE sciencemag.orgCONTENTS657,680,&687Designer proteins 6 MAY 2016 VOLUME 352 ISSUE 6286RESEARCHIN BRIEF 668 From Science and other journalsREVIEW671 CELLULAR DYNAMICSNongenetic functions of the genome M.Bustin and T.MisteliREVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad6933RESEARCH ARTICLES 672 NEUROSCIENCEAutism-associated SHANK3 haploinsuf ciency causes Ih channelopathy in human neurons F.Yi et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf2669673 PRIMATE EVOLUTIONOligocene primates from China reveal divergence between African and Asian primate evolution X.Ni et al.677 ASTROPARTICLE PHYSICSObservation of the 60Fe nucleosynthesis-clock isotope in galactic cosmic rays W.R.Binns et al.680 PROTEIN DESIGNDe novo design of protein homo-oligomers with modular hydrogen-bond networkmediated specifi city S.E.Boyken et al.PERSPECTIVE P.657;REPORT P.687REPORTS 687 PROTEIN DESIGNDesign of structurally distinct proteins using strategies inspired by evolution T.M.Jacobs et al.PERSPECTIVE P.657;RESEARCH ARTICLE P.680691 MICROFLUIDICSSubmillisecond organic synthesis:Outpacing Fries rearrangement through microfl uidic rapid mixing H.Kim et al.694 GEOMORPHOLOGYSelf-organization of river channels as a critical fi lter on climate signals C.B.Phillips and D.J.Jerolmack697 POLYMER GROWTHUniform patchy and hollow rectangular platelet micelles from crystallizable polymer blends H.Qiu et al.PERSPECTIVE P.656701 GEOPHYSICSSlow slip near the trench at the Hikurangi subduction zone,New Zealand L.M.Wallace et al.PERSPECTIVE P.654705 GEOBIOLOGYMass-dependent and-independent signature of Fe isotopes in magnetotactic bacteria M.Amor et al.708 DEMOGRAPHYInequality in mortality decreased among the young while increasing for older adults,19902010 J.Currie and H.Schwandt PERSPECTIVE P.661712 NEURODEVELOPMENTComplement and microglia mediate early synapse loss in Alzheimer mouse models S.Hong et al.717 EPIGENETICSSingle-molecule decoding of combinatorially modifi ed nucleosomes E.Shema et al.721 CELL BIOLOGYMicrotubule doublets are double-track railways for intrafl agellar transport trains L.Stepanek and G.Pigino725 PROTEIN STRUCTUREFemtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein K.Pande et al.ON THE COVERIntrafl agellar transport(IFT)in the cilium of a eukaryotic cell.IFT trains use microtubule doublets as bidirectional railways to transport ciliary building blocks.Assigning directionality to individual microtubules ensures that trains moving forward(purple)and backward(red)do not collide.Thus,traf c jams are avoided during assembly and disassembly of the cilium.See page 721.Illustration:C.Bickel/ScienceSCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last w