Science 2016-02-12.pdf

12 FEBRUARY 2016 VOL 351 ISSUE 6274 637SCIENCE sciencemag.org12 FEBRUARY 2016 VOLUME 351 ISSUE 6274CONTENTSNEWSIN BRIEF642 News at a glanceIN DEPTH 645 TRIUMPH FOR GRAVITATIONAL WAVE HUNTObservation made with newly detectable radiation clinches case for black holes By A.Cho647 BENDY BUGS INSPIRE ROBOTICISTSBees,wasps,and cockroaches are built to survive bashing and squeezing By E.Pennisi648 NEANDERTAL GENES LINKED TO MODERN DISEASESDNA inherited from our extinct cousins boosts risk of depression,other disorders By A.Gibbons REPORT P.737649 RESEARCH CHIEF CUTS CLIMATE STUDIES,SETS NEW PRIORITIESCSIRO to trim staff as it seeks closer alignment with industry By L.Dayton650 RECORD OZONE HOLE MAY OPEN OVER ARCTIC IN THE SPRINGUnusual polar cold produces clouds that could help push ozone losses beyond 2011 mark,releasing extra UV radiation By E.Hand651 A CRYSTAL BALL FOR CHEMICAL SAFETYBy comparing new chemicals to known compounds,toxicologists seek early hazard warning By T.RabesandratanaFEATURE 652 AFTER THE ACCUSATIONA complex case of alleged sexual misconduct rattles a field and signals a cultural shift By M.Balter664 CLIMATE CONFUSION AMONG U.S.TEACHERSTeachers knowledge and values can hinder climate education By E.Plutzer et al.666 COPPER CATALYSIS IN A BLUE LIGHTVisible light,copper,and a phosphine ligand combine for C-N bond formation at fully substituted chiral centers By M.F.Greaney REPORT P.681667 IT TAKES TEAMWORK TO MODIFY CHROMATINThe organization of constituents in a large chromatin-modifying complex reveals specific roles By J.L.Workman REPORT P.725668 FINDING AN ETHICAL PATH FORWARD FOR MITOCHONDRIAL REPLACEMENTIt is ethically permissible to initiate clinical investigations of mitochondrial replacement techniques in humans so long as significant conditions and restrictions are in place By A.B.Claiborne et al.670(TORC)ING UP PURINE BIOSYNTHESISAn enzyme complex coordinates metabolism and nucleotide production to fuel cell growth By E.H.Ma and R.G.Jones REPORTS PP.728&733BOOKS ET AL.672 THE SECRET WORLD INSIDE YOUR.DeSalle and S.Perkins,curators,reviewed by V.Thompson673 UNINFORMEDBy A.Lupia,reviewed by J.Junn673 THE HUMAN FACE OF BIG DATAS.Smolan,directorLETTERS 674 THE CRUSHING WEIGHT OF URBAN WASTEBy H.Yang et al.674 CHINAS PARTIAL EMISSION CONTROLBy A.Lin et al.675 MISGUIDED STRATEGYFOR MOSQUITO CONTROLBy V.M.Azevedo-Santos et al.667&725Modular cooperation controls transcriptionINSIGHTSPERSPECTIVES 658 A NEW DIET FOR METHANE OXIDIZERSArchaea that normally depend on sulfate-reducing bacteria can also grow alone By A.-E.Rotaru and B.Thamdrup REPORT P.703659 PATHOGEN TO POWERHOUSEHow did the precursors to the mitochondrion and the plastid evade host defense?By S.G.Ball et al.661 A UNIFYING MODEL OF EPIGENETIC REGULATIONSingle-cell tracking reveals a common“algorithm”of operation used by chromatin regulators By A.J.Keung and A.S.Khalil REPORT P.720662 MODULATING PULMONARY INFLAMMATIONNeuroepithelial cells suppress pulmonary inflammation and alveolar remodeling By J.A.Whitsett and E.E.Morrisey REPORT P.707645Published by AAASon February 11,2016Downloaded from on February 11,2016Downloaded from 12 FEBRUARY 2016 VOL 351 ISSUE 6274 639SCIENCE sciencemag.orgCONTENTS12 FEBRUARY 2016 VOLUME 351 ISSUE 6274RESEARCHIN BRIEF 676 From Science and other journalsREVIEW679 GENE REGULATIONRetrotransposons as regulators of gene expression R.A.Elbarbary et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aac7247RESEARCH ARTICLE 680 GENE REGULATIONLineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells E.L.Soucie et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad5510 REPORTS 681 PHOTOCATALYSISAsymmetric copper-catalyzed C-N cross-couplings induced by visible light Q.M.Kainz et al.PERSPECTIVE P.666684 PLANT IMMUNITYUsing decoys to expand the recognition specificity of a plant disease resistance protein S.H.Kim et al.688 VALLEYTRONICSValley-polarized exciton dynamics in a 2D semiconductor heterostructure P.Rivera et al.691 MATERIALS SCIENCEOn-chip and freestanding elastic carbon films for micro-supercapacitors P.Huang et al.696 CARBON CYCLEEnhanced seasonal CO2 exchange caused by amplified plant productivity in northern ecosystems M.Forkel et al.699 GLOBAL WATER CYCLEA decade of sea level rise slowed by climate-driven hydrology J.T.Reager et al.703 MICROBIAL PHYSIOLOGYArtificial electron acceptors decouple archaeal methane oxidation from sulfate reduction S.Scheller et al.PERSPECTIVE P.658707 LUNG PHYSIOLOGYPulmonary neuroendocrine cells function as airway sensors to control lung immune response K.Branchfield et al.PERSPECTIVE P.662711 AUTOIMMUNITYPathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion T.Delong et al.714 IMMUNOLOGYBroadly targeted CD8+T cell responses restricted by major histocompatibility complex E S.G.Hansen et al.720 EPIGENETICSDynamics of epigenetic regulation at the single-cell level L.Bintu et