Science 2018-12-07.pdf

CREDITS:(TOP TO BOTTOM)JOSHUA BIRD/SCIENCE;STEPHAN SCHMITZ/FOLIO ART;IMAGEBROKER/ALAMY STOCK PHOTO7 DECEMBER 2018 VOL 362 ISSUE 6419 1083SCIENCE sciencemag.org7 DECEMBER 2018 VOLUME 362 ISSUE 6419CONTENTS1116Adapting tissue regeneration1100NEWSIN BRIEF1088 News at a glanceIN DEPTH 1090 WHAT NOW FOR HUMAN GENOME EDITING?Claimed creation of CRISPR-edited babies triggers calls for international oversight By J.Cohen1091 For China,a CRISPR first goes too far By D.Normile1092 UNCERTAINTY BOOSTS BREXIT JITTERS FOR U.K.SCIENTISTSPolitical turmoil in Parliament threatens a disastrous crash out of the European Union By E.Stokstad1094 UNIVERSAL FLU VACCINE IS AN ALCHEMISTS DREAMThe rapidly changing virus and a complex immune response stymie vaccine developers By J.Cohen1113 CLIMATE CHANGE AND MARINE MASS EXTINCTIONThe end of the Permian Period was catastrophic for life in high-latitude regions By L.Kump RESEARCH ARTICLE P.11301114 BIOENERGETICS THROUGHTHICK AND THINMembrane fluidity influences the efficiency of oxidative energy metabolism By E.A.Schon REPORT P.11861116 ENDOTHELIAL CELL ADAPTATION IN REGENERATIONTissue-specific endothelial cells maintain organ homeostasis and instruct regeneration By J.M.Gomez-Salinero and S.Rafii1118 MASTERING BOARD GAMESA single algorithm can learn to play three hard board games By M.Campbell EDITORIAL P.1087;REPORT P.1140POLICY FORUM 1119 FLAWED ANALYSES OF U.S.AUTO FUEL ECONOMY STANDARDSA 2018 analysis discarded at least$112 billion in benefits By A.M.Bento et al.LETTERS 1122 MODEL VS.EXPERIMENT TO PREDICT CROP LOSSESBy C.Parmesan et al.1122 Response By C.A.Deutsch et al.1123 NO CONFLICT OF INTEREST IN DATA MONITORINGBy J.L.HalperinINSIGHTSBOOKS ET AL.1104 BOOKS FOR BUDDING SCIENTISTSPERSPECTIVES 1111 BARRIER(LESS)ISLANDSNo stopping 1D crystals By B.Kahr and M.D.Ward REPORT P.11351112 TOWARD A CHEMICAL VACCINE FOR MALARIAA high-throughput screen puts us on the road to protecting populations against malaria By M.A.Phillips and D.E.Goldberg RESEARCH ARTICLE P.11291095 DEMOTION DISMAYS RESEARCHERS AT STORIED DANISH MUSEUMMerger with biology department could undermine research By G.VogelFEATURES 1096 TAKING AIMAfter her own violent childhood,emergency physician Rebecca Cunningham is jump-starting research to prevent gun deaths in kids By M.Wadman PODCAST1100 AT ARMS LENGTHMajor private research funders make secretive offshore investments,raising ethical concerns By C.Piller PODCAST1122Published by AAASon December 10,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(TOP TO BOTTOM)E.HAECKEL;ROBERT NEUBECKER7 DECEMBER 2018 VOL 362 ISSUE 6419 1085SCIENCE sciencemag.orgCONTENTS1113&1130Warming and hypoxia drove Permian extinction7 DECEMBER 2018 VOLUME 362 ISSUE 64191140 COMPUTER SCIENCEA general reinforcement learning algorithm that masters chess,shogi,and Go through self-play D.Silver et al.EDITORIAL P.1087;PERSPECTIVE P.11181144 BATTERIESRoom-temperature cycling of metal fluoride electrodes:Liquid electrolytes for high-energy fluoride ion cells V.K.Davis et al.1149 VALLEYTRONICSA valley valve and electron beam splitter J.Li et al.1153 QUANTUM MATERIALSPhotonic crystals for nano-light in moir graphene superlattices S.S.Sunku et al.1156 MICROBIOLOGYSalmonella persisters undermine host immune defenses during antibiotic treatment D.A.C.Stapels et al.1161 HUMAN GENETICSQuantifying the contribution of recessive coding variation to developmental disorders H.C.Martin et al.1165 CANCERA mechanistic classification of clinical phenotypes in neuroblastoma S.Ackermann et al.SIGNAL TRANSDUCTION1171 LZTR1 is a regulator of RAS ubiquitination and signaling J.W.Bigenzahn et al.1177 Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination M.Steklov et al.1182 MOLECULAR BIOLOGYA DNA methylation reader complex that enhances gene transcription C.J.Harris et al.ON THE COVERStarting from random play and given no domain knowledge except the game rules,the AlphaZero program taught itself to play chess,shogi,and Go,defeating a world cham-pion program in each game.Blue translucent pieces represent AlphaZeros possible moves;percentages indicate the predicted outcome.A single algorithm that can master several complex problems is an important step toward creating a general-purpose machine learn-ing system to tackle real-world problems.See pages 1087,1118,and 1140.Image:DeepMind Technologies Limited SCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2018 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership,including subscription(12 months):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1808;Foreign postage extra:Mexico,Caribb