Science 2016-10-07.pdf

7 OCTOBER 2016 VOL 354 ISSUE 6308 7SCIENCE sciencemag.org7 OCTOBER 2016 VOLUME 354 ISSUE 6308CONTENTSNEWSIN BRIEF16 News at a glanceIN DEPTH 18 BATTLE OVER RARE DISEASE DRUG ENSNARES NIHFirms and parents of kids with fatal condition clash over drug delivery and role of agency By M.Wadman20 NOBEL HONORS DISCOVERIES IN HOW CELLS EAT THEMSELVESCellular sanitation helps keep diseases at bay By M.Enserink and E.Pennisi21 TRIO WINS NOBEL FOR EFFECTS OF TOPOLOGY ON EXOTIC MATTERWork presaged research revolution in topological insulators By A.Cho22 EUROPEAN XFEL TO SHINE AS BRIGHTEST,FASTEST X-RAY SOURCEFree electron lasers rapid-fire pulses will probe free-floating molecules in their natural habitat By E.Cartlidge23 U.S.CHARGES JOURNAL PUBLISHER WITH MISLEADING AUTHORSOMICS Group Inc.has drawn numerous complaints about allegedly shady editorial practices and meetings By J.Bohannon24 FIRST POLYNESIANS LAUNCHED FROM EAST ASIA TO SETTLE PACIFIC“Game-changing”study of ancient genomes traces Polynesian roots solely to East Asian farmers By A.GibbonsON THE COVERA Sherpa porter at the base of the Khumbu Ice Fall,Mount Everest.Some human populations exhibit greater tolerance for high elevation,due to genetic variants that likely mitigate the deleterious effects of low oxygen concentrations at altitude.Genetic and epigenetic changes shape our response to the environment and may play a role in disease.For more on the interactions between genes and the environment,see page 52.Photo:Max Lowe/National Geographic CreativeSPECIAL SECTIONGENES&ENVIRONMENTINTRODUCTION 52 Genes under pressureREVIEWS54 Going global by adapting local:A review of recent human adaptation S.Fan et al.59 Transgenerational inher-itance:Models and mechanisms of nonDNA sequencebased inheritance E.A.Miska and A.C.Ferguson-Smith64 Writ large:Genomic dissection of the effect of cellular environment on immune response N.Yosef and A.Regev69 Exposing the exposures responsible for type 2 diabetes and obesity P.W.Franks and M.I.McCarthy EDITORIAL P.1538&81INSIGHTSPERSPECTIVES 32 GROWING A SYNTHETIC MOLLUSK SHELLThree-dimensional organic templates control calcium carbonate precipitation By F.Barthelat REPORT P.10734 A PRAGMATIC WAY FORWARD?Training of informal providers may improve the quality of primary health care in rural India By T.Powell-Jackson RESEARCH ARTICLE P.8035 COLD ATOMS TWISTING SPINAND MOMENTUMUltracold atoms can simulate complex quantum systems By M.Aidelsburger RESEARCH ARTICLE P.8336 THE MIFstep IN PARTHANATOSPreventing cells from killing themselves may save tissues from damage during disease By E.Jonas RESEARCH ARTICLE P.8238 HUMAN BRAINS TEACH US A SURPRISING LESSONYoung interneurons continue migrating to the frontal lobe during the first few months of life By M.McKenzie and G.Fishell RESEARCH ARTICLE P.81FEATURE 26 RESCUING THE GUARDIAN OF THE GENOMENew drugs combat cancer by propping up a mutated tumor-fighting protein By R.F.Service26Fixing a brokencancer suppressorDA_1007TOC.indd 710/5/16 11:18 AMPublished by AAAS on October 8,2016http:/science.sciencemag.org/Downloaded from 7 OCTOBER 2016 VOL 354 ISSUE 6308 9SCIENCE sciencemag.orgCONTENTS35&83Cold atoms mimicking condensed matter7 OCTOBER 2016 VOLUME 354 ISSUE 6308RESEARCHIN BRIEF 77 From Science and other journalsRESEARCH ARTICLES 80 HEALTH ECONOMICSThe impact of training informal health care providers in India:A randomized controlled trial J.Das et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf7384 PERSPECTIVE P.3481 NEURODEVELOPMENTExtensive migration of young neurons into the infant human frontal lobe M.F.Paredes et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf7073 PERSPECTIVE P.38;PODCAST82 CELL DEATHA nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose)polymerase-1 Y.Wang et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad6872 PERSPECTIVE P.3683 QUANTUM SIMULATIONRealization of two-dimensional spin-orbit coupling for Bose-Einstein condensates Z.Wu et al.PERSPECTIVE P.35REPORTS 88 GEOPHYSICSLocalized seismic deformation in the upper mantle revealed by dense seismic arrays A.Inbal et al.92 SOLAR CELLSQuantum dotinduced phase stabilization of a-CsPbI3 perovskite for high-efficiency photovoltaics A.Swarnkar et al.96 QUANTUM GASESUltrafast many-body interferometry of impurities coupled to a Fermi sea M.Cetina et al.99 DEVICE TECHNOLOGYMoS2 transistors with 1-nanometer gate lengths S.B.Desai et al.102 BIOCATALYSISAn artificial metalloenzyme with the kinetics of native enzymes P.Dydio et al.107 BIOINSPIRED MATERIALSSynthetic nacre by predesigned matrix-directed mineralization L.-B.Mao et al.PERSPECTIVE P.32110 COGNITIONGreat apes anticipate that other individuals will act according to false beliefs C.Krupenye et al.PERSPECTIVE P.39;VIDEO114 STRUCTURAL BIOLOGYThe methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 4Fe-4S clusters T.Wagner et al.SCIENCE(ISSN 0036-8075)is