Science 2016-05-20.pdf

INSIGHTSLETTERS 886 INGENUITY:NEXTGENS VISION URBAN PLANET SECTION P.904 PERSPECTIVES 890 CHANGING OF THE GUARDDNA nanostructures mimic membrane proteins By S.Howorka891 SUPERCONDUCTIVITY ON THE EDGEHybrid correlated systems could reveal exotic quantum transport behavior By N.Mason REPORT P.966892 METHANEMAKE IT OR BREAK ITBiochemical data resolve the controversy over how methanogenic archaea produce methane By T.J.Lawton and A.C.Rosenzweig RESEARCH ARTICLE P.953INTRODUCTION 904 Cities are the futureNEWS906 Rise of the city908 Roots of the urban mind By G.Miller912 A plague of rats By W.Cornwall916 China rethinks cities By D.Normile918 Vancouvers green dream By K.R.WeissREVIEWS922 City-integrated renewable energy for urban sustainability D.M.Kammen and D.A.Sunter928 Emerging solutions to the water challenges of an urbanizing world T.A.Larsen et al.PERSPECTIVES934 Transport solutions for cleaner air F.J.Kelly and T.Zhu936 The ecological future of cities M.J.McDonnell and I.MacGregor-Fors938 Living in cities,naturally T.Hartig and P.H.Kahn Jr.940 Meta-principles for developing smart,sustainable,and healthy cities A.Ramaswami et al.943 Hidden linkages between urbanization and food systems K.C.Seto and N.Ramankutty946 Building functional cities J.V.Henderson et al.ON THE COVERMassive fog rolls into Dubai,United Arab Emirates.As host to more than half of the worlds population,cities have foot-prints that reach well beyond their municipal boundaries.Ef orts are now under way to make urban areas more sustainable and ef cient.The challenges and opportunities of our urban planet are highlighted in a special section beginning on page 904 and online at http:/scim.ag/1Tb0WdZ.Photo:Sebastian Opitz/Novarc Images868 20 MAY 2016 VOL 352 ISSUE 6288sciencemag.org SCIENCE20 MAY 2016 VOLUME 352 ISSUE 6288CONTENTS890Membrane-bending DNA nanostructuresNEWSIN BRIEF874 News at a glanceIN DEPTH 876 TRACKING HOW HUMANS EVOLVE IN REAL TIMEAnalyses of thousands of sequenced genomes show changes in as little as a generation By E.Pennisi877 CELL PAINTING HIGHLIGHTS RESPONSES TO DRUGS AND TOXINSMachine learning combined with molecular paints allows rapid screening of changes in cell shape and function By E.Pennisi878 RESEARCHERS DECRY CONSENT PROPOSALU.S.would require patient permission for use of anonymous tissue samples By J.KaiserSPECIAL SECTIONURBAN PLANETSEE ALSO EDITORIAL P.873 LETTERS P.886 PODCAST VIDEO879 A MODULAR ROUTE TO NEW ANTIBIOTICSDivide-and-conquer chemistry yields hundreds of candidate medicines By R.F.Service880 DATA CHECK:EMPLOYMENT CRISIS FOR NEW PH.D.S IS AN ILLUSIONNSF surveys generate what seem to be confl icting data on the status of those entering the scientifi c job market By J.Mervis881 CAN BRAIN SCANS REVEAL CONCUSSION-LINKED DISEASE?By highlighting condition typically confirmed by autopsy,protein tracer could alter medical and legal landscape By E.Underwood FEATURE 882 THE TRUEST TESTStudies that intentionally infect people with pathogens have a checkered past,but they are seeing a resurgence By J.Cohen8MemMemDNADNAPublished by AAAS on May 19,2016http:/science.sciencemag.org/Downloaded from 20 MAY 2016 VOL 352 ISSUE 6288 869SCIENCE sciencemag.org986Sensing cellular phosphate895&978Robots that perch Science Staf .870New Products.1014Science Careers.1015DEPARTMENTS873 EDITORIAL Leave no city behindBy Michele Acuto and Susan Parnell URBAN PLANET SECTION P.9041022 WORKING LIFEA problem by any other name By Paul Rogge and Emily RegierRESEARCHIN BRIEF 949 From Science and other journalsRESEARCH ARTICLES 952 CANCER IMMUNOTHERAPYThe tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas D.F.Quail et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad3018953 ENZYME MECHANISMSThe radical mechanism of biological methane synthesis by methyl-coenzyme M reductase T.Wongnate et al.PERSPECTIVE P.892REPORTS 958 SUPERCONDUCTIVITYUbiquitous signatures of nematic quantum criticality in optimally doped Fe-based superconductors H.-H.Kuo et al.962 ARTIFICIAL SPIN ICERewritable artifi cial magnetic charge ice Y.-L.Wang et al.966 SUPERCONDUCTIVITYSupercurrent in the quantum Hall regime F.Amet et al.PERSPECTIVE P.891969 CATALYSISQuantifying the promotion of Cu catalysts by ZnO for methanol synthesis S.Kuld et al.974 CATALYSISSelf-assembly of noble metal monolayers on transition metal carbide nanoparticle catalysts S.T.Hunt et al.978 ROBOTICSPerching and takeof of a robotic insect on overhangs using switchable electrostatic adhesion M.A.Graule et al.PERSPECTIVE P.895;VIDEO982 SYNAPSE FORMATIONControl of neuronal synapse specifi cation by a highly dedicated alternative splicing program L.Traunmller et al.SCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing of c