Science 2018-09-28.pdf

CREDITS(FROM TOP):COLDQUANTA INC.;FOREAL;CNRI/SCIENCE SOURCE28 SEPTEMBER 2018 VOL 361 ISSUE 6409 1285SCIENCE sciencemag.org28 SEPTEMBER 2018 VOLUME 361 ISSUE 6409CONTENTSNEWSIN BRIEF1294 News at a glanceIN DEPTH 1298 CLASSIC WOLF-MOOSE STUDY TO BE RESTARTED ON ISLE ROYALEWolf airlift will reboot worlds longest running predator-prey study,ended by climate change,inbreeding By C.Mlot 1299 NSF ISSUES SEXUAL HARASSMENT POLICY AS NIH PROMISES ACTIONFunding agencies face challenge of sanctioning grantees found guilty without disrupting academic research By J.Mervis and J.Kaiser1300 ATOMIC ARRAYS POWER QUANTUM COMPUTERSNeutral atoms rise as dark horse qubit candidate By S.ChenINTRODUCTION 1330 Forces behind formREVIEWS1332 Chromatin plasticity:A versatile landscape that underlies cell fate and identity T.Yadav et al.1336 Dynamic DNA methylation:In the right place at the right time C.Luo et al.1341 Developmental enhancers and chromosome topology E.E.M.Furlong and M.Levine1346 RNA modifications modulate gene expression during development M.Frye et al.INSIGHTSPERSPECTIVES 1308 THE MAKING OF A PLANKTON TOXINA combined genetic and chemical study reveals the biosynthetic steps involved in making the toxin domoic acid By G.Pohnert et al.REPORT P.13561310 HOX GENES AND BODY SEGMENTATIONAn ancient gene cluster controls the formation of repetitive body parts in a sea anemone By D.Arendt GENES IN DEVELOPMENT SECTION P.1330;REPORT P.13771311 NO STRAND LEFT BEHINDHistone chaperones direct how epigenetic information is inherited in dividing cells By K.Ahmad and S.Henikoff REPORTS PP.1386&13891313 ABOVE AND BELOW THE MAYA FORESTAdvanced remote sensing technology raises questions about settlement and land use By A.Ford and S.Horn RESEARCH ARTICLE P.13551314 HOW DORMANT CANCER PERSISTS AND REAWAKENSInsights reveal possible avenues to prevent metastasis By J.A.Aguirre-Ghiso RESEARCH ARTICLE P.13531316 ELECTRO-OPTIC COMBS RISE ABOVE THE NOISEElectro-optic modulation of light can have a precision equivalent to one optical-field cycle By V.Torres-Company REPORT P.1358POLICY FORUM 1317 CANCER PREVENTION:MOLECULAR AND EPIDEMIOLOGIC CONSENSUSResearch in many fields emphasizes the value of prevention By M.Song et al.BOOKS ET AL.1319 STORIES OF THE SANGUINEA meandering history of blood tackles transfusions,taboos,and trauma By S.E.Lederer1302 OLD GENOME EDITORS MIGHT TREAT MITOCHONDRIAL DISEASESIn mice,disrupting mutant DNA appears to relieve its effects By M.Leslie1303 COOL PAINT JOB FIGHTS SOLAR WARMTHNew material could reduce cost of cooling buildings by reflecting light and shedding heat By R.F.ServiceFEATURE 1304 BRIDGING THE GAPIn a bid to ease a history of mistrust,a summer workshop trains Indigenous scientists in genomics By L.Wade PODCASTON THE COVERIn balloon art,the sculptor exerts precise forces at specific sites to make identifiable body parts.Likewise,choreographed molecular mechanisms,albeit at a complex and tightly controlled level,enable a few seemingly identical starting cells to transform into a whole animal.This special issue highlights the regulatory mechanisms controlling gene expres-sion,depicted in the background here as a heat map.See page 1330.Graphic:FOREALSEE ALSO PERSPECTIVE P.1310 RESEARCH ARTICLE P.1354 REPORTS PP.1377&1380 RESEARCH ARTICLE BY T.GERBER ET AL.10.1126/science.aaq0681SPECIAL SECTIONGENES IN DEVELOPMENT1300Computing with captive atoms 1302Published by AAASon October 3,2018 http:/science.sciencemag.org/Downloaded from CREDITS:(FROM TOP):ADAPTED BY N.CARY/SCIENCE FROM K.AHMAD;FAIRFAX MEDIA/FAIRFAX MEDIA/GETTY IMAGES;ROBERT NEUBECKER28 SEPTEMBER 2018 VOL 361 ISSUE 6409 1287SCIENCE sciencemag.orgCONTENTS28 SEPTEMBER 2018 VOLUME 361 ISSUE 6409RESEARCHIN BRIEF 1350 From Science and other journalsRESEARCH ARTICLES 1353 CANCERNeutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice J.Albrengues et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aao4227 PERSPECTIVE P.13141354 EPIGENOMICSAllele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci V.Onuchic et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aar3146 GENES IN DEVELOPMENT SECTION P.13301380 SINGLE-CELL GENOMICSJoint profiling of chromatin accessibility and gene expression in thousands of single cells J.Cao et al.GENES IN DEVELOPMENT SECTION P.1330MOLECULAR BIOLOGY1386 A mechanism for preventing asymmetric histone segregation onto replicating DNA strands C.Yu et al.1389 MCM2 promotes symmetric inheritance of modified histones during DNA replication N.Petryk et al.PERSPECTIVE P.1311SCIENCE(ISSN 0036-8075)is published weekly on Friday,except last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing offices.Copyright 2018 by the American Association for the Advancement of Sci